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ENZYME entry: EC 3.1.1.93

Accepted Name
mycophenolic acid acyl-glucuronide esterase.
Alternative Name(s)
AcMPAG deglucuronidase.
mycophenolic acid acyl-glucuronide deglucuronidase.
Reaction catalysed
H2O + mycophenolic acid O-acyl-beta-D-glucuronide <=> D-glucuronate + H(+) + mycophenolate
Comment(s)
This liver enzyme deglucuronidates mycophenolic acid O-acyl- glucuronide, a metabolite of the immunosuppressant drug mycophenolate that is thought to be immunotoxic.
Cross-references
BRENDA3.1.1.93
EC2PDB3.1.1.93
ExplorEnz3.1.1.93
PRIAM enzyme-specific profiles3.1.1.93
KEGG Ligand Database for Enzyme Nomenclature3.1.1.93
IUBMB Enzyme Nomenclature3.1.1.93
IntEnz3.1.1.93
MEDLINEFind literature relating to 3.1.1.93
MetaCyc3.1.1.93
Rhea expert-curated reactions3.1.1.93
UniProtKB/Swiss-Prot
Q5E9H9, ABHDA_BOVIN;  Q9NUJ1, ABHDA_HUMAN;  Q6PE15, ABHDA_MOUSE;  
Q5REX5, ABHDA_PONAB;  Q5I0K5, ABHDA_RAT;  

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