ENZYME entry: EC 3.1.11.8
| Accepted Name |
|---|
| Guaosine-5'-diphospho-5'-(DNA) diphosphatase.
|
| Alternative Name(s) |
|---|
| Aprataxin. |
| Pp5'G5'-DNA guanylate hydrolase. |
| Pp5'G5'DNA diphosphatase. |
| Reaction catalysed |
|---|
| Guanosine-5'-diphospho-5'-(DNA) + H(2)O <=> phospho-5'-(DNA) + GMP |
| Comment(s) |
|---|
- Aprataxin is a DNA-binding protein that catalyzes (among other
activities) the 5' decapping of Gpp-DNA (formed by homologs of RtcB3
from the bacterium Myxococcus xanthus).
- The enzyme binds the guanylate group to a histidine residue at its
active site, forming a covalent enzyme-nucleotide phosphate
intermediate, followed by the hydrolysis of the guanylate from the
nucleic acid and eventual release.
- The enzyme forms a 5'-phospho terminus that can be efficiently joined
by 'classical' ligases.
- The enzyme also possesses the activity of EC 3.1.11.7 and
EC 3.1.12.2.
|
| Cross-references |
|---|
| BRENDA | 3.1.11.8 |
| EC2PDB | 3.1.11.8 |
| ExplorEnz | 3.1.11.8 |
| PRIAM enzyme-specific profiles | 3.1.11.8 |
| KEGG Ligand Database for Enzyme Nomenclature | 3.1.11.8 |
| IUBMB Enzyme Nomenclature | 3.1.11.8 |
| IntEnz | 3.1.11.8 |
| MEDLINE | Find literature relating to 3.1.11.8 |
| MetaCyc | 3.1.11.8 |
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