ENZYME entry: EC 3.1.11.8

Accepted Name
Guaosine-5'-diphospho-5'-(DNA) diphosphatase.
Alternative Name(s)
Aprataxin.
Pp5'G5'-DNA guanylate hydrolase.
Pp5'G5'DNA diphosphatase.
Reaction catalysed
Guanosine-5'-diphospho-5'-(DNA) + H(2)O <=> phospho-5'-(DNA) + GMP
Comment(s)
  • Aprataxin is a DNA-binding protein that catalyzes (among other activities) the 5' decapping of Gpp-DNA (formed by homologs of RtcB3 from the bacterium Myxococcus xanthus).
  • The enzyme binds the guanylate group to a histidine residue at its active site, forming a covalent enzyme-nucleotide phosphate intermediate, followed by the hydrolysis of the guanylate from the nucleic acid and eventual release.
  • The enzyme forms a 5'-phospho terminus that can be efficiently joined by 'classical' ligases.
  • The enzyme also possesses the activitiy of EC 3.1.11.7 and EC 3.1.12.2.
Cross-references
BRENDA3.1.11.8
EC2PDB3.1.11.8
ExplorEnz3.1.11.8
PRIAM enzyme-specific profiles3.1.11.8
KEGG Ligand Database for Enzyme Nomenclature3.1.11.8
IUBMB Enzyme Nomenclature3.1.11.8
IntEnz3.1.11.8
MEDLINEFind literature relating to 3.1.11.8
MetaCyc3.1.11.8

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