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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC

Accepted Name
Choloyl-CoA hydrolase.
Alternative Name(s)
Chenodeoxycholoyl-coenzyme A thioesterase.
Choloyl-coenzyme A thioesterase.
Peroxisomal acyl-CoA thioesterase 2.
Reaction catalysed
Choloyl-CoA + H(2)O <=> cholate + CoA
  • Also acts on chenodeoxycholoyl-CoA and to a lesser extent on short- and medium- to long-chain acyl-CoA's, and other substrates, including trihydroxycoprostanoyl-CoA, hydroxymethylglutaryl-CoA and branched chain acyl-CoA's, all of which are present in peroxisomes.
  • The enzyme is strongly inhibited by CoA and may be involved in controlling CoA levels in the peroxisome.
PRIAM enzyme-specific profiles3.1.2.27
KEGG Ligand Database for Enzyme Nomenclature3.1.2.27
IUBMB Enzyme Nomenclature3.1.2.27
MEDLINEFind literature relating to
O14734, ACOT8_HUMAN;  P58137, ACOT8_MOUSE;  Q8VHK0, ACOT8_RAT;  

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