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ENZYME entry: EC 3.1.2.27

Accepted Name
Choloyl-CoA hydrolase.
Alternative Name(s)
Chenodeoxycholoyl-coenzyme A thioesterase.
Choloyl-coenzyme A thioesterase.
Peroxisomal acyl-CoA thioesterase 2.
PTE-2.
Reaction catalysed
Choloyl-CoA + H(2)O <=> cholate + CoA
Comment(s)
  • Also acts on chenodeoxycholoyl-CoA and to a lesser extent on short- and medium- to long-chain acyl-CoA's, and other substrates, including trihydroxycoprostanoyl-CoA, hydroxymethylglutaryl-CoA and branched chain acyl-CoA's, all of which are present in peroxisomes.
  • The enzyme is strongly inhibited by CoA and may be involved in controlling CoA levels in the peroxisome.
Cross-references
BRENDA3.1.2.27
EC2PDB3.1.2.27
ExplorEnz3.1.2.27
PRIAM enzyme-specific profiles3.1.2.27
KEGG Ligand Database for Enzyme Nomenclature3.1.2.27
IUBMB Enzyme Nomenclature3.1.2.27
IntEnz3.1.2.27
MEDLINEFind literature relating to 3.1.2.27
MetaCyc3.1.2.27
Rhea expert-curated reactions3.1.2.27
UniProtKB/Swiss-Prot
O14734, ACOT8_HUMAN;  P58137, ACOT8_MOUSE;  Q8VHK0, ACOT8_RAT;  
Q14032, BAAT_HUMAN;  Q91X34, BAAT_MOUSE;  Q63276, BAAT_RAT;  

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