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ENZYME entry: EC 3.1.21.1

Accepted Name
deoxyribonuclease I.
Alternative Name(s)
DNase.
pancreatic DNase.
thymonuclease.
Reaction catalysed
Endonucleolytic cleavage to 5'-phosphodinucleotide and 5'-phosphooligonucleotide end-products
Comment(s)
  • Preference for double-stranded DNA.
  • Similar enzymes: streptococcal DNase (streptodornase), T4 endonuclease II, T7 endonuclease II, Escherichia coli endonuclease I, 'nicking' nuclease of calf thymus, colicin E2 and E3.
  • Formerly EC 3.1.4.5.
Cross-references
BRENDA3.1.21.1
EC2PDB3.1.21.1
ExplorEnz3.1.21.1
PRIAM enzyme-specific profiles3.1.21.1
KEGG Ligand Database for Enzyme Nomenclature3.1.21.1
IUBMB Enzyme Nomenclature3.1.21.1
IntEnz3.1.21.1
MEDLINEFind literature relating to 3.1.21.1
MetaCyc3.1.21.1
Rhea expert-curated reactions3.1.21.1
UniProtKB/Swiss-Prot
U2UMQ6, CS12A_ACISB;  A0Q7Q2, CS12A_FRATN;  P00639, DNAS1_BOVIN;  
Q767J3, DNAS1_CANLF;  Q9YGI5, DNAS1_CHICK;  Q4AEE3, DNAS1_HORSE;  
P24855, DNAS1_HUMAN;  P49183, DNAS1_MOUSE;  O42446, DNAS1_OREMO;  
P11936, DNAS1_PIG;  O18998, DNAS1_RABIT;  P21704, DNAS1_RAT;  
P11937, DNAS1_SHEEP;  P26295, DRN1_STREQ;  P57487, END1_BUCAI;  
Q89AD7, END1_BUCBP;  P25736, END1_ECOLI;  Q9I733, TSE7_PSEAE;  

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