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ENZYME

ENZYME entry: EC 3.1.21.2

Accepted Name
deoxyribonuclease IV
Alternative Name(s)
deoxyribonuclease IV (phage T4-induced)
endodeoxyribonuclease IV (phage T4-induced)
endonuclease II
endonuclease IV
Reaction catalysed
Endonucleolytic cleavage to 5'-phosphooligonucleotide end-products
Comment(s)
  • The enzyme is an apurinic/apyrimidinic (AP) site endonuclease that primes DNA repair synthesis at AP sites.
  • It specifically cleaves the DNA backbone at AP sites and also removes 3' DNA-blocking groups such as 3' phosphates, 3' phosphoglycolates, and 3' alpha,beta-unsaturated aldehydes that arise from oxidative base damage and the activity of combined glycosylase/lyase enzymes.
  • It is also the only known repair enzyme that is able to cleave the DNA backbone 5' of the oxidative lesion alpha-deoxyadenosine.
  • The enzyme has a strong preference for single-stranded DNA.
  • Formerly EC 3.1.4.30.
Cross-references
BRENDA3.1.21.2
EC2PDB3.1.21.2
ExplorEnz3.1.21.2
PRIAM enzyme-specific profiles3.1.21.2
KEGG Ligand Database for Enzyme Nomenclature3.1.21.2
IUBMB Enzyme Nomenclature3.1.21.2
IntEnz3.1.21.2
MEDLINEFind literature relating to 3.1.21.2
MetaCyc3.1.21.2
Rhea expert-curated reactions3.1.21.2
UniProtKB/Swiss-Prot
A9NFH1, END4_ACHLIA3MZ76, END4_ACTP2B3H0M0, END4_ACTP7
B0BTA9, END4_ACTPJA0KK26, END4_AERHHA4SMZ0, END4_AERS4
B2UQE3, END4_AKKM8A8EWW1, END4_ALIB4Q5WHC2, END4_ALKCK
A8ML82, END4_ALKOOB7GH81, END4_ANOFWO67551, END4_AQUAE
Q2NJF9, END4_AYWBPC3P8J1, END4_BACAAC3LKW3, END4_BACAC
A0RIQ8, END4_BACAHQ81LV1, END4_BACANB7JN09, END4_BACC0
B7IYD6, END4_BACC2C1ES07, END4_BACC3B7HCQ9, END4_BACC4
B7HPI4, END4_BACC7A7GSY1, END4_BACCNB9IY53, END4_BACCQ
Q818H3, END4_BACCRQ634Q3, END4_BACCZQ5LG28, END4_BACFN
Q64WY5, END4_BACFRQ6HDN3, END4_BACHKQ65HA0, END4_BACLD
A9VHR4, END4_BACMKP54476, END4_BACSUQ89YT0, END4_BACTN
A7Z6S8, END4_BACVZB3DS13, END4_BIFLDQ8G689, END4_BIFLO
B7GRN1, END4_BIFLSB8D8T8, END4_BUCA5P57237, END4_BUCAI
P59058, END4_BUCAPB8D742, END4_BUCATP59496, END4_BUCBP
A8Z6D9, END4_CAMC1A7GW36, END4_CAMC5A0RRG4, END4_CAMFF
A7I010, END4_CAMHCQ3ABA7, END4_CARHZA0RYW7, END4_CENSY
A9WII8, END4_CHLAAQ5L798, END4_CHLABB8G418, END4_CHLAD
Q3AT74, END4_CHLCHQ824X6, END4_CHLCVB3EEJ7, END4_CHLL2
Q3B5R5, END4_CHLL3Q9PJB8, END4_CHLMUB3QQA9, END4_CHLP8
B3ELV8, END4_CHLPBA4SDE2, END4_CHLPMQ9Z7H3, END4_CHLPN
B9LAM9, END4_CHLSYB0B8K0, END4_CHLT2Q3KL70, END4_CHLTA
B0BA79, END4_CHLTBQ8KFL0, END4_CHLTEO84630, END4_CHLTR
B5EAS8, END4_CITBBA8AE66, END4_CITK8A6LQV9, END4_CLOB8
B2V158, END4_CLOBAB2TL64, END4_CLOBBQ189A4, END4_CLOD6
A7MLL2, END4_CROS8C0QMG1, END4_DESAHA8ZSE7, END4_DESOH
Q6ASE4, END4_DESPSQ72CQ9, END4_DESVHA1VEI5, END4_DESVV
Q966U0, END4_DICDIA7ZNY3, END4_ECO24B7UFH5, END4_ECO27
B7MF74, END4_ECO45B7LAI2, END4_ECO55P0A6C2, END4_ECO57
B5YWV0, END4_ECO5EB7NMX3, END4_ECO7IB7MX24, END4_ECO81
B7M507, END4_ECO8AC4ZU09, END4_ECOBWB1X857, END4_ECODH
A8A222, END4_ECOHSA1AD18, END4_ECOK1Q0TFT1, END4_ECOL5
Q8FFU0, END4_ECOL6B1IYB0, END4_ECOLCP0A6C1, END4_ECOLI
B7N5C2, END4_ECOLUB6I8L0, END4_ECOSEB1LKQ6, END4_ECOSM
Q1R9R2, END4_ECOUTC5BCN2, END4_EDWI9A4WCJ5, END4_ENT38
Q834D0, END4_ENTFAB2VIH1, END4_ERWT9B7LVB9, END4_ESCF3
B1YL88, END4_EXIS2B0S196, END4_FINM2B9M4N1, END4_GEODF
Q5KX27, END4_GEOKAQ74FS7, END4_GEOSLC6DYE3, END4_GEOSM
C5D4R0, END4_GEOSWA4IR02, END4_GEOTNB8F7D1, END4_GLAP5
Q7VMC4, END4_HAEDUQ9KD33, END4_HALH5A1WXM0, END4_HALHL
Q5V0S8, END4_HALMAB8CW79, END4_HALOHB0R2U6, END4_HALS3
Q9HSK7, END4_HALSAQ18KA6, END4_HALWDB0TD39, END4_HELMI
A9B5N7, END4_HERA2B5XP51, END4_KLEP3A6TBP4, END4_KLEP7
A9KNS9, END4_LACP7Q88VR2, END4_LACPLQ38XB2, END4_LATSS
Q92BR0, END4_LISINC1KV96, END4_LISMCQ71ZM1, END4_LISMF
Q8Y756, END4_LISMOA0AIQ1, END4_LISW6B1HTF6, END4_LYSSC
A0L901, END4_MAGMMQ8EWT2, END4_MALP2Q6F1D3, END4_MESFL
Q601Y6, END4_MESH2Q4A8V0, END4_MESH7Q4AAX4, END4_MESHJ
Q6KH96, END4_MESM1B3PMH1, END4_META1A2SPZ6, END4_METLZ
A3CT71, END4_METMJB8GKX5, END4_METPEQ2NFM3, END4_METST
Q5UPY4, END4_MIMIVQ2RJF1, END4_MOOTAA5IYT8, END4_MYCAP
P63536, END4_MYCBOA1KGF0, END4_MYCBPC1AL03, END4_MYCBT
Q2ST57, END4_MYCCTQ7NBA9, END4_MYCGAP47477, END4_MYCGE
B8ZSC5, END4_MYCLBP30770, END4_MYCLEB2HSJ8, END4_MYCMM
Q6MUC7, END4_MYCMSP75457, END4_MYCPNQ98PU8, END4_MYCPU
Q4A6S5, END4_MYCS5A5U056, END4_MYCTAP9WQ12, END4_MYCTO
P9WQ13, END4_MYCTUA0PM27, END4_MYCUAQ3IMK8, END4_NATPD
B2A499, END4_NATTJB9L9K0, END4_NAUPAA9A555, END4_NITMS
A6Q1P1, END4_NITSBQ8EPZ2, END4_OCEIHQ30YP7, END4_OLEA2
Q6YQC1, END4_ONYPEA6LB99, END4_PARD8Q6MED0, END4_PARUW
Q6D3L8, END4_PECASC6DEL1, END4_PECCPQ03F56, END4_PEDPA
B4SE58, END4_PELPBC0QRI1, END4_PERMHA9BJ15, END4_PETMO
Q7N364, END4_PHOLLQ6LUP5, END4_PHOPRA6L330, END4_PHOV8
B4S3I3, END4_PROA2B4ETA5, END4_PROMHB5EYQ5, END4_SALA4
A9MK49, END4_SALARQ57MD6, END4_SALCHB5FNK8, END4_SALDC
B5R173, END4_SALEPB5RC42, END4_SALG2B4TAM6, END4_SALHS
B4SY37, END4_SALNSQ5PE50, END4_SALPAA9N6I5, END4_SALPB
C0Q0T7, END4_SALPCB5BE34, END4_SALPKB4TNR0, END4_SALSV
Q8Z593, END4_SALTIQ8ZNK6, END4_SALTYA8GGT5, END4_SERP5
B2TVT4, END4_SHIB3Q31YW6, END4_SHIBSQ32EQ7, END4_SHIDS
Q0T2W5, END4_SHIF8Q83QW6, END4_SHIFLQ3Z047, END4_SHISS
Q01TU5, END4_SOLUEA7X2V2, END4_STAA1A6U229, END4_STAA2
Q2FGG6, END4_STAA3Q2FY16, END4_STAA8A5IT85, END4_STAA9
Q2YT22, END4_STAABQ5HFK3, END4_STAACA6QHA0, END4_STAAE
P63537, END4_STAAMP63538, END4_STAANQ6GGE2, END4_STAAR
Q6G909, END4_STAASA8Z497, END4_STAATP63539, END4_STAAW
B9DNM8, END4_STACTQ5HNZ1, END4_STAEQQ8CP25, END4_STAES
Q4L6Q7, END4_STAHJQ49Y00, END4_STAS1Q82AG6, END4_STRAW
Q9S2N2, END4_STRCOQ30PH2, END4_SULDNA6QCI0, END4_SULNB
B2V7A4, END4_SULSYQ67S99, END4_SYMTHB7IDS7, END4_THEAB
Q9HJS3, END4_THEACA6LMU8, END4_THEM4Q9WYJ7, END4_THEMA
O86954, END4_THENEB9KBS2, END4_THENNA5IK54, END4_THEP1
B1L9C6, END4_THESQQ72KH8, END4_THET2Q97A09, END4_THEVO
C4LD49, END4_TOLATB3E325, END4_TRIL1Q9PQI5, END4_UREPA
B5ZBB4, END4_UREU1A7MS84, END4_VIBC1A5F5R6, END4_VIBC3
Q9KPK7, END4_VIBCHC3LQD2, END4_VIBCMQ87SC6, END4_VIBPA
Q8DEP6, END4_VIBVUQ7MNR1, END4_VIBVYQ7M8B4, END4_WOLSU
A1JLX8, END4_YERE8P42691, END4_YERENA7FK62, END4_YERP3
Q1C982, END4_YERPAB2K9J1, END4_YERPBQ8ZGJ1, END4_YERPE
A9R4S1, END4_YERPGQ1CG79, END4_YERPNA4TNA4, END4_YERPP
Q66CR5, END4_YERPSB1JRM5, END4_YERPYP00641, ENDO_BPT7
P20314, ENRN_BPT3

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All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.1.21.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.1.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.-.-.-