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ENZYME entry: EC 3.1.21.2

Accepted Name
Deoxyribonuclease IV.
Alternative Name(s)
Deoxyribonuclease IV (phage T4-induced).
Endodeoxyribonuclease IV (phage T(4)-induced).
Endodeoxyribonuclease IV (phage T4-induced).
Endonuclease II.
Endonuclease IV.
Reaction catalysed
Endonucleolytic cleavage to 5'-phosphooligonucleotide end-products
Comment(s)
  • The enzyme is an apurinic/apyrimidinic (AP) site endonuclease that primes DNA repair synthesis at AP sites.
  • It specifically cleaves the DNA backbone at AP sites and also removes 3' DNA-blocking groups such as 3' phosphates, 3' phosphoglycolates, and 3' alpha,beta-unsaturated aldehydes that arise from oxidative base damage and the activity of combined glycosylase/lyase enzymes.
  • It is also the only known repair enzyme that is able to cleave the DNA backbone 5' of the oxidative lesion alpha-deoxyadenosine.
  • The enzyme has a strong preference for single-stranded DNA.
  • Formerly EC 3.1.4.30.
Cross-references
PROSITEPDOC00599
BRENDA3.1.21.2
EC2PDB3.1.21.2
ExplorEnz3.1.21.2
PRIAM enzyme-specific profiles3.1.21.2
KEGG Ligand Database for Enzyme Nomenclature3.1.21.2
IUBMB Enzyme Nomenclature3.1.21.2
IntEnz3.1.21.2
MEDLINEFind literature relating to 3.1.21.2
MetaCyc3.1.21.2
Rhea expert-curated reactions3.1.21.2
UniProtKB/Swiss-Prot
A9NFH1, END4_ACHLI;  A3MZ76, END4_ACTP2;  B3H0M0, END4_ACTP7;  
B0BTA9, END4_ACTPJ;  A0KK26, END4_AERHH;  A4SMZ0, END4_AERS4;  
B2UQE3, END4_AKKM8;  A8ML82, END4_ALKOO;  B7GH81, END4_ANOFW;  
O67551, END4_AQUAE;  A8EWW1, END4_ARCB4;  Q2NJF9, END4_AYWBP;  
C3P8J1, END4_BACAA;  C3LKW3, END4_BACAC;  A0RIQ8, END4_BACAH;  
Q81LV1, END4_BACAN;  B7JN09, END4_BACC0;  B7IYD6, END4_BACC2;  
C1ES07, END4_BACC3;  B7HCQ9, END4_BACC4;  B7HPI4, END4_BACC7;  
A7GSY1, END4_BACCN;  B9IY53, END4_BACCQ;  Q818H3, END4_BACCR;  
Q634Q3, END4_BACCZ;  Q5LG28, END4_BACFN;  Q64WY5, END4_BACFR;  
Q9KD33, END4_BACHD;  Q6HDN3, END4_BACHK;  Q65HA0, END4_BACLD;  
A9VHR4, END4_BACMK;  Q5WHC2, END4_BACSK;  P54476, END4_BACSU;  
Q89YT0, END4_BACTN;  A6L330, END4_BACV8;  A7Z6S8, END4_BACVZ;  
B3DS13, END4_BIFLD;  Q8G689, END4_BIFLO;  B7GRN1, END4_BIFLS;  
B8D8T8, END4_BUCA5;  P57237, END4_BUCAI;  P59058, END4_BUCAP;  
B8D742, END4_BUCAT;  P59496, END4_BUCBP;  A8Z6D9, END4_CAMC1;  
A7GW36, END4_CAMC5;  A0RRG4, END4_CAMFF;  A7I010, END4_CAMHC;  
Q3ABA7, END4_CARHZ;  A0RYW7, END4_CENSY;  A9WII8, END4_CHLAA;  
Q5L798, END4_CHLAB;  B8G418, END4_CHLAD;  Q3AT74, END4_CHLCH;  
Q824X6, END4_CHLCV;  B3EEJ7, END4_CHLL2;  Q9PJB8, END4_CHLMU;  
B3QQA9, END4_CHLP8;  B3ELV8, END4_CHLPB;  A4SDE2, END4_CHLPM;  
Q9Z7H3, END4_CHLPN;  B9LAM9, END4_CHLSY;  B0B8K0, END4_CHLT2;  
Q3KL70, END4_CHLTA;  B0BA79, END4_CHLTB;  Q8KFL0, END4_CHLTE;  
O84630, END4_CHLTR;  A8AE66, END4_CITK8;  A6LQV9, END4_CLOB8;  
B2V158, END4_CLOBA;  B2TL64, END4_CLOBB;  Q189A4, END4_CLOD6;  
A7MLL2, END4_CROS8;  Q30YP7, END4_DESAG;  C0QMG1, END4_DESAH;  
A8ZSE7, END4_DESOH;  Q6ASE4, END4_DESPS;  Q72CQ9, END4_DESVH;  
A1VEI5, END4_DESVV;  Q966U0, END4_DICDI;  A7ZNY3, END4_ECO24;  
B7UFH5, END4_ECO27;  B7MF74, END4_ECO45;  B7LAI2, END4_ECO55;  
P0A6C2, END4_ECO57;  B5YWV0, END4_ECO5E;  B7NMX3, END4_ECO7I;  
B7MX24, END4_ECO81;  B7M507, END4_ECO8A;  C4ZU09, END4_ECOBW;  
B1X857, END4_ECODH;  A8A222, END4_ECOHS;  A1AD18, END4_ECOK1;  
Q0TFT1, END4_ECOL5;  Q8FFU0, END4_ECOL6;  B1IYB0, END4_ECOLC;  
P0A6C1, END4_ECOLI;  B7N5C2, END4_ECOLU;  B6I8L0, END4_ECOSE;  
B1LKQ6, END4_ECOSM;  Q1R9R2, END4_ECOUT;  C5BCN2, END4_EDWI9;  
A4WCJ5, END4_ENT38;  Q834D0, END4_ENTFA;  B2VIH1, END4_ERWT9;  
B7LVB9, END4_ESCF3;  B1YL88, END4_EXIS2;  B0S196, END4_FINM2;  
B5EAS8, END4_GEOBB;  B9M4N1, END4_GEODF;  Q5KX27, END4_GEOKA;  
B3E325, END4_GEOLS;  Q74FS7, END4_GEOSL;  C6DYE3, END4_GEOSM;  
C5D4R0, END4_GEOSW;  A4IR02, END4_GEOTN;  Q7VMC4, END4_HAEDU;  
B8F7D1, END4_HAEPS;  A1WXM0, END4_HALHL;  Q5V0S8, END4_HALMA;  
B8CW79, END4_HALOH;  B0R2U6, END4_HALS3;  Q9HSK7, END4_HALSA;  
Q18KA6, END4_HALWD;  B0TD39, END4_HELMI;  A9B5N7, END4_HERA2;  
B5XP51, END4_KLEP3;  A6TBP4, END4_KLEP7;  A9KNS9, END4_LACP7;  
Q88VR2, END4_LACPL;  Q38XB2, END4_LACSS;  Q92BR0, END4_LISIN;  
C1KV96, END4_LISMC;  Q71ZM1, END4_LISMF;  Q8Y756, END4_LISMO;  
A0AIQ1, END4_LISW6;  B1HTF6, END4_LYSSC;  A0L901, END4_MAGMM;  
Q6F1D3, END4_MESFL;  A2SPZ6, END4_METLZ;  A3CT71, END4_METMJ;  
B8GKX5, END4_METPE;  Q2NFM3, END4_METST;  Q5UPY4, END4_MIMIV;  
Q2RJF1, END4_MOOTA;  B3PMH1, END4_MYCA5;  A5IYT8, END4_MYCAP;  
P63536, END4_MYCBO;  A1KGF0, END4_MYCBP;  C1AL03, END4_MYCBT;  
Q2ST57, END4_MYCCT;  Q7NBA9, END4_MYCGA;  P47477, END4_MYCGE;  
Q601Y6, END4_MYCH2;  Q4A8V0, END4_MYCH7;  Q4AAX4, END4_MYCHJ;  
B8ZSC5, END4_MYCLB;  P30770, END4_MYCLE;  B2HSJ8, END4_MYCMM;  
Q6KH96, END4_MYCMO;  Q6MUC7, END4_MYCMS;  Q8EWT2, END4_MYCPE;  
P75457, END4_MYCPN;  Q98PU8, END4_MYCPU;  Q4A6S5, END4_MYCS5;  
A5U056, END4_MYCTA;  P9WQ12, END4_MYCTO;  P9WQ13, END4_MYCTU;  
A0PM27, END4_MYCUA;  Q3IMK8, END4_NATPD;  B2A499, END4_NATTJ;  
B9L9K0, END4_NAUPA;  A9A555, END4_NITMS;  A6Q1P1, END4_NITSB;  
Q8EPZ2, END4_OCEIH;  Q6YQC1, END4_ONYPE;  A6LB99, END4_PARD8;  
Q6MED0, END4_PARUW;  Q6D3L8, END4_PECAS;  C6DEL1, END4_PECCP;  
Q03F56, END4_PEDPA;  Q3B5R5, END4_PELLD;  B4SE58, END4_PELPB;  
C0QRI1, END4_PERMH;  A9BJ15, END4_PETMO;  Q7N364, END4_PHOLL;  
Q6LUP5, END4_PHOPR;  B4S3I3, END4_PROA2;  B4ETA5, END4_PROMH;  
B5EYQ5, END4_SALA4;  A9MK49, END4_SALAR;  Q57MD6, END4_SALCH;  
B5FNK8, END4_SALDC;  B5R173, END4_SALEP;  B5RC42, END4_SALG2;  
B4TAM6, END4_SALHS;  B4SY37, END4_SALNS;  Q5PE50, END4_SALPA;  
A9N6I5, END4_SALPB;  C0Q0T7, END4_SALPC;  B5BE34, END4_SALPK;  
B4TNR0, END4_SALSV;  Q8Z593, END4_SALTI;  Q8ZNK6, END4_SALTY;  
A8GGT5, END4_SERP5;  B2TVT4, END4_SHIB3;  Q31YW6, END4_SHIBS;  
Q32EQ7, END4_SHIDS;  Q0T2W5, END4_SHIF8;  Q83QW6, END4_SHIFL;  
Q3Z047, END4_SHISS;  Q01TU5, END4_SOLUE;  A7X2V2, END4_STAA1;  
A6U229, END4_STAA2;  Q2FGG6, END4_STAA3;  Q2FY16, END4_STAA8;  
A5IT85, END4_STAA9;  Q2YT22, END4_STAAB;  Q5HFK3, END4_STAAC;  
A6QHA0, END4_STAAE;  P63537, END4_STAAM;  P63538, END4_STAAN;  
Q6GGE2, END4_STAAR;  Q6G909, END4_STAAS;  A8Z497, END4_STAAT;  
P63539, END4_STAAW;  B9DNM8, END4_STACT;  Q5HNZ1, END4_STAEQ;  
Q8CP25, END4_STAES;  Q4L6Q7, END4_STAHJ;  Q49Y00, END4_STAS1;  
Q82AG6, END4_STRAW;  Q9S2N2, END4_STRCO;  Q30PH2, END4_SULDN;  
A6QCI0, END4_SULNB;  B2V7A4, END4_SULSY;  Q67S99, END4_SYMTH;  
B7IDS7, END4_THEAB;  Q9HJS3, END4_THEAC;  A6LMU8, END4_THEM4;  
Q9WYJ7, END4_THEMA;  O86954, END4_THENE;  B9KBS2, END4_THENN;  
A5IK54, END4_THEP1;  B1L9C6, END4_THESQ;  Q72KH8, END4_THET2;  
Q97A09, END4_THEVO;  C4LD49, END4_TOLAT;  Q9PQI5, END4_UREPA;  
B5ZBB4, END4_UREU1;  A5F5R6, END4_VIBC3;  A7MS84, END4_VIBCB;  
Q9KPK7, END4_VIBCH;  C3LQD2, END4_VIBCM;  Q87SC6, END4_VIBPA;  
Q8DEP6, END4_VIBVU;  Q7MNR1, END4_VIBVY;  Q7M8B4, END4_WOLSU;  
A1JLX8, END4_YERE8;  P42691, END4_YEREN;  A7FK62, END4_YERP3;  
Q1C982, END4_YERPA;  B2K9J1, END4_YERPB;  Q8ZGJ1, END4_YERPE;  
A9R4S1, END4_YERPG;  Q1CG79, END4_YERPN;  A4TNA4, END4_YERPP;  
Q66CR5, END4_YERPS;  B1JRM5, END4_YERPY;  P00641, ENDO_BPT7;  
P20314, ENRN_BPT3;  

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