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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC 3.1.21.4

Accepted Name
Type II site-specific deoxyribonuclease.
Alternative Name(s)
Type II restriction enzyme.
Reaction catalysed
Endonucleolytic cleavage of DNA to give specific double-stranded fragments with terminal 5'-phosphates
Cofactor(s)
Mg(2+).
Comment(s)
  • Large group of enzymes which recognize specific short DNA sequences and cleave either within, or at a short specific distance from, the recognition site.
  • See the REBASE database for a complete list of these enzymes: http://rebase.neb.com/rebase/
Cross-references
BRENDA3.1.21.4
EC2PDB3.1.21.4
ExplorEnz3.1.21.4
PRIAM enzyme-specific profiles3.1.21.4
KEGG Ligand Database for Enzyme Nomenclature3.1.21.4
IUBMB Enzyme Nomenclature3.1.21.4
IntEnz3.1.21.4
MEDLINEFind literature relating to 3.1.21.4
MetaCyc3.1.21.4
UniProtKB/Swiss-Prot
P25239, T257_ECOLX;  O52703, T2A1_ACEPA;  P24546, T2A1_ACICA;  
P0A458, T2A1_ANAVA;  P26919, T2A1_AZOBR;  P0A457, T2A1_NOSS1;  
Q9KHV6, T2A1_THAGE;  D4ZX34, T2AP_ARTPN;  O68557, T2B1_BACIU;  
P70985, T2B1_GEOSE;  P25257, T2B1_HERAU;  Q50973, T2B1_NEIGO;  
Q45488, T2B2_BACIU;  Q50975, T2B5_NEIGO;  P43419, T2B6_BACSF;  
P19887, T2BA_ANEAE;  P23940, T2BA_BACAM;  P33562, T2BB_BACIU;  
P25217, T2BF_BACIU;  Q9LAI1, T2BLA_BACSQ;  Q9LAI0, T2BLB_BACSQ;  
P06529, T2BR_BACIU;  Q04852, T2C1_CITFR;  P25258, T2C1_HERAU;  
P52283, T2C1_PBCVI;  P42827, T2C1_RHOHA;  P17743, T2C2_HAEIF;  
P25259, T2C2_HERAU;  P31117, T2C2_PBCV1;  Q60132, T2C9_CITFR;  
P56200, T2CX_CITFR;  P05301, T2D1_DESNO;  P24599, T2D1_HERAU;  
Q9RLM3, T2D1_NEIMC;  P0A459, T2D1_STRPN;  P0A460, T2D1_STRR6;  
P44413, T2D2_HAEIN;  P09357, T2D2_STREE;  P43870, T2D3_HAEIN;  
P44999, T2D5_HAEIN;  P00642, T2E1_ECOLX;  P25260, T2E1_HERAU;  
P14633, T2E2_ECOLX;  P04390, T2E5_ECOLX;  P50194, T2E7_ECOLX;  
P50195, T2E8_ECOLX;  P20588, T2F1_HAEIF;  P14870, T2F1_PLAOK;  
Q50976, T2F7_NEIGO;  P43418, T2G1_AVIPA;  P25261, T2G1_HERAU;  
P29537, T2H1_HAEPA;  P50191, T2H1_HAEPH;  O30869, T2H2_HAEAE;  
P36433, T2H2_HAEPA;  P00643, T2H2_HAEPH;  O68584, T2H3_HAEAE;  
P25237, T2K1_KLEPN;  P50177, T2L2_LACLC;  Q58391, T2M1_METJA;  
P50189, T2M1_MICAM;  P34719, T2M1_MORBO;  P11405, T2M1_MORSP;  
Q58844, T2M2_METJA;  P23191, T2M2_MORBO;  Q58017, T2M3_METJA;  
Q58723, T2M4_METJA;  P31032, T2M4_NEIGO;  Q58895, T2M5_METJA;  
P81326, T2M6_METJA;  P29565, T2MT_METTF;  P43642, T2MU_MYCSP;  
O59646, T2MW_METWO;  P29566, T2MZ_METTF;  P50187, T2N1_NOCAE;  
Q51083, T2N3_NEILA;  P50183, T2N4_NEILA;  P35677, T2N5_NOSS7;  
P31031, T2P1_PROHU;  P24617, T2P2_NEIGO;  P23657, T2P2_PROHU;  
P05104, T2P7_PSEAI;  P00640, T2PS_PROST;  P21763, T2R1_RHOSH;  
O34104, T2S1_LACLC;  P09796, T2S1_SALIN;  O31074, T2S1_STRAH;  
Q53608, T2S1_STRAL;  O52691, T2S1_STRCS;  O52512, T2S1_STRFI;  
P29346, T2S1_STRSA;  P34880, T2S2_SHISO;  P16667, T2S3_STAAU;  
P23736, T2S9_STAAU;  P14229, T2SM_SERMA;  P29748, T2T8_THET8;  
P14386, T2TA_THEAQ;  P43421, T2V1_GEOSE;  P30773, T2X1_XANCC;  
P96189, T2X1_XANCR;  Q9KVZ7, T2X1_XANVA;  P36693, TERL_BPP21;  
P03708, TERL_LAMBD;  O35025, YDIR_BACSU;  O34885, YDIS_BACSU;  
O34303, YDJA_BACSU;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.1.21.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.1.-.-
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