A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.
ENZYME entry: EC 3.1.26.12
| Accepted Name |
|---|
| Ribonuclease E.
|
| Alternative Name(s) |
|---|
| Endoribonuclease E. |
| RNase E. |
| Reaction catalysed |
|---|
| Endonucleolytic cleavage of single-stranded RNA in A- and U-rich regions |
| Comment(s) |
|---|
- RNase E is a bacterial ribonuclease that plays a role in the
processing of ribosomal RNA (9S to 5S rRNA), the chemical degradation
of bulk cellular RNA, the decay of specific regulatory, messenger and
structural RNAs and the control of plasmid DNA replication.
- The enzyme binds to monophosphorylated 5' ends of substrates but
exhibits sequential cleavages in the 3' to 5' direction.
- 2'-O-methyl nucleotide substitutions at RNase E binding sites do not
prevent binding but do prevent cleavage of non-modified target
sequences 5' to that locus.
- In Escherichia coli, the enzyme is found in the RNA degradosome.
- The C-terminal half of the protein contains binding sites for the
three other major degradosomal components, the DEAD-box RNA helicase
Rh1B, EC 4.1.1.11 and EC 2.7.7.8.
- Formerly EC 3.1.26.n1.
|
| Cross-references |
|---|
| BRENDA | 3.1.26.12 |
| EC2PDB | 3.1.26.12 |
| ExplorEnz | 3.1.26.12 |
| PRIAM enzyme-specific profiles | 3.1.26.12 |
| KEGG Ligand Database for Enzyme Nomenclature | 3.1.26.12 |
| IUBMB Enzyme Nomenclature | 3.1.26.12 |
| IntEnz | 3.1.26.12 |
| MEDLINE | Find literature relating to 3.1.26.12 |
| MetaCyc | 3.1.26.12 |
| UniProtKB/Swiss-Prot |
|
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