ID   3.1.26.13
DE   retroviral ribonuclease H.
CA   Endohydrolysis of RNA in RNA/DNA hybrids. Three different cleavage modes:
CA   1. sequence-specific internal cleavage of RNA. Human immunodeficiency
CA   virus type 1 and Moloney murine leukemia virus enzymes prefer to cleave
CA   the RNA strand one nucleotide away from the RNA-DNA junction. 2. RNA
CA   5'-end directed cleavage 13-19 nucleotides from the RNA end. 3. DNA
CA   3'-end directed cleavage 15-20 nucleotides away from the primer terminus.
CC   -!- Retroviral reverse transcriptase is a multifunctional enzyme
CC       responsible for viral replication.
CC   -!- To perform this task the enzyme combines two distinct activities.
CC   -!- The polymerase domain (EC 2.7.7.49) occupies the N-terminal two-
CC       thirds of the reverse transcriptase whereas the ribonuclease H domain
CC       comprises the C-terminal remaining one-third.
CC   -!- The RNase H domain of Moloney murine leukemia virus and Human
CC       immunodeficiency virus display two metal binding sites.
DR   P19560, POL_BIV29  ;  P33459, POL_CAEVC  ;  P11204, POL_EIAV9  ;
DR   P32542, POL_EIAVC  ;  P03371, POL_EIAVY  ;  P16088, POL_FIVPE  ;
DR   P19028, POL_FIVSD  ;  P31822, POL_FIVT2  ;  O93215, POL_HV190  ;
DR   O12158, POL_HV192  ;  O89290, POL_HV193  ;  Q9QBY3, POL_HV196  ;
DR   Q9QBZ9, POL_HV197  ;  O41798, POL_HV19N  ;  P03369, POL_HV1A2  ;
DR   Q77373, POL_HV1AN  ;  P03366, POL_HV1B1  ;  P04587, POL_HV1B5  ;
DR   Q73368, POL_HV1B9  ;  P03367, POL_HV1BR  ;  P04589, POL_HV1EL  ;
DR   Q75002, POL_HV1ET  ;  P04585, POL_HV1H2  ;  P20875, POL_HV1JR  ;
DR   P0C6F2, POL_HV1LW  ;  Q9QBZ1, POL_HV1M2  ;  P04588, POL_HV1MA  ;
DR   P05961, POL_HV1MN  ;  Q9QBZ5, POL_HV1MP  ;  Q79666, POL_HV1MV  ;
DR   P12497, POL_HV1N5  ;  P18802, POL_HV1ND  ;  P20892, POL_HV1OY  ;
DR   P05959, POL_HV1RH  ;  Q9WC54, POL_HV1S2  ;  Q9WC63, POL_HV1S9  ;
DR   O89940, POL_HV1SE  ;  P24740, POL_HV1U4  ;  Q9Q720, POL_HV1V9  ;
DR   Q9QSR3, POL_HV1VI  ;  P35963, POL_HV1Y2  ;  Q9IDV9, POL_HV1YB  ;
DR   O91080, POL_HV1YF  ;  P12499, POL_HV1Z2  ;  P18096, POL_HV2BE  ;
DR   P24107, POL_HV2CA  ;  P17757, POL_HV2D1  ;  P15833, POL_HV2D2  ;
DR   Q89928, POL_HV2EH  ;  P18042, POL_HV2G1  ;  Q74120, POL_HV2KR  ;
DR   P05962, POL_HV2NZ  ;  P04584, POL_HV2RO  ;  P12451, POL_HV2SB  ;
DR   P20876, POL_HV2ST  ;  Q76634, POL_HV2UC  ;  Q82851, POL_JEMBR  ;
DR   P16901, POL_OMVVS  ;  P17283, POL_SIVCZ  ;  Q1A249, POL_SIVEK  ;
DR   Q02836, POL_SIVG1  ;  P22382, POL_SIVGB  ;  P05896, POL_SIVM1  ;
DR   Q1A267, POL_SIVMB  ;  P05897, POL_SIVMK  ;  P12502, POL_SIVS4  ;
DR   P19505, POL_SIVSP  ;  Q8AII1, POL_SIVTN  ;  P27973, POL_SIVV1  ;
DR   P27980, POL_SIVVG  ;  P05895, POL_SIVVT  ;
//