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ENZYME

ENZYME entry: EC 3.1.26.3

Accepted Name
ribonuclease III
Alternative Name(s)
ribonuclease 3
RNase III
Reaction catalysed
Endonucleolytic cleavage to 5'-phosphomonoester
Comment(s)
  • An endoribonuclease that cleaves double-stranded RNA molecules.
  • The cleavage can be either a single-stranded nick or double-stranded break in the RNA, depending in part upon the degree of base-pairing in the region of the cleavage site.
  • Specificity is conferred by negative determinants, i.e., the presence of certain Watson-Crick base-pairs at specific positions that strongly inhibit cleavage.
  • RNase III is involved in both rRNA processing and mRNA processing and decay.
Cross-references
BRENDA3.1.26.3
EC2PDB3.1.26.3
ExplorEnz3.1.26.3
PRIAM enzyme-specific profiles3.1.26.3
KEGG Ligand Database for Enzyme Nomenclature3.1.26.3
IUBMB Enzyme Nomenclature3.1.26.3
IntEnz3.1.26.3
MEDLINEFind literature relating to 3.1.26.3
MetaCyc3.1.26.3
Rhea expert-curated reactions3.1.26.3
UniProtKB/Swiss-Prot
Q9VCU9, DCR1_DROMEA1ZAW0, DCR2_DROMEQ6TUI4, DICER_BOVIN
Q25BN1, DICER_CHICKA0MQH0, DICER_CRIGRQ6TV19, DICER_DANRE
Q9UPY3, DICER_HUMANQ8R418, DICER_MOUSEB3DLA6, DICER_XENTR
P22192, PAC1_SCHPOQ8Z023, RNC1_NOSS1P74368, RNC1_SYNY3
Q8YPT4, RNC2_NOSS1Q55637, RNC2_SYNY3Q6F9C2, RNC_ACIAD
B7GYT0, RNC_ACIB3B0VTM5, RNC_ACIBSA3M7P2, RNC_ACIBT
B0VCU0, RNC_ACIBYF0KKL2, RNC_ACICPA3MZQ9, RNC_ACTP2
B0BUA6, RNC_ACTPJA6VLV8, RNC_ACTSZQ8UGK2, RNC_AGRFC
Q21XN1, RNC_ALBFTQ0VP19, RNC_ALCBSA8EV88, RNC_ALIB4
Q5E314, RNC_ALIF1Q0A8Z1, RNC_ALKEHB9JUN7, RNC_ALLAM
B9KGT5, RNC_ANAMFQ5P9U8, RNC_ANAMMQ2GIW0, RNC_ANAPZ
B7GGE9, RNC_ANOFWO67082, RNC_AQUAEQ5P086, RNC_AROAE
Q2NJY3, RNC_AYWBPA8I3B5, RNC_AZOC5B6YQI6, RNC_AZOPC
C1DQS2, RNC_AZOVDC3P5Q0, RNC_BACAAC3L778, RNC_BACAC
Q81WI8, RNC_BACANB7JJT6, RNC_BACC0Q732M1, RNC_BACC1
B7IUK8, RNC_BACC2C1EP73, RNC_BACC3B7HDX2, RNC_BACC4
B7HLI2, RNC_BACC7A7GRH9, RNC_BACCNB9IVD8, RNC_BACCQ
Q819V8, RNC_BACCRQ636H7, RNC_BACCZQ5LIS2, RNC_BACFN
Q64ZV9, RNC_BACFRQ6HEW6, RNC_BACHKQ65JQ5, RNC_BACLD
A9VT87, RNC_BACMKP51833, RNC_BACSUQ8A2E8, RNC_BACTN
A7Z4L3, RNC_BACVZA1US36, RNC_BARBKQ6G459, RNC_BARHE
Q6G082, RNC_BARQUA9IRN0, RNC_BART1Q6MLR5, RNC_BDEBA
Q8G7H1, RNC_BIFLOQ7VRR0, RNC_BLOFLQ492D1, RNC_BLOPB
Q2KWY0, RNC_BORA1Q0SMF0, RNC_BORAPQ7WD32, RNC_BORBR
O51648, RNC_BORBUQ660G7, RNC_BORGPQ7W5J6, RNC_BORPA
A9IIJ2, RNC_BORPDQ7VW39, RNC_BORPEO69161, RNC_BRADU
B2SAD9, RNC_BRUA1Q2YN02, RNC_BRUA2Q57E81, RNC_BRUAB
A9MA35, RNC_BRUC2C0RI03, RNC_BRUMBP66664, RNC_BRUME
B0CKY7, RNC_BRUSIP66665, RNC_BRUSUB8D951, RNC_BUCA5
P57346, RNC_BUCAIQ8K9R1, RNC_BUCAPB8D7F5, RNC_BUCAT
P59476, RNC_BUCBPQ057R4, RNC_BUCCCQ61XX9, RNC_CAEBR
O01326, RNC_CAEELQ8R9W3, RNC_CALS4A8Z6F6, RNC_CAMC1
A7H186, RNC_CAMC5A0RRM7, RNC_CAMFFA8FNU7, RNC_CAMJ8
A7H5Y2, RNC_CAMJDQ9PM40, RNC_CAMJEQ5HSF8, RNC_CAMJR
Q3AC58, RNC_CARHZB0T3I0, RNC_CAUSKQ9A805, RNC_CAUVC
B8H627, RNC_CAUVNA3PGF8, RNC_CERS1Q3J5W1, RNC_CERS4
A4WVP5, RNC_CERS5B9KSA7, RNC_CERSKA9WJ69, RNC_CHLAA
Q5L6E3, RNC_CHLABB8GAM6, RNC_CHLADQ3AQ14, RNC_CHLCH
Q823R4, RNC_CHLCVQ253V2, RNC_CHLFFQ3B6L3, RNC_CHLL3
Q9PK97, RNC_CHLMUQ9Z9C7, RNC_CHLPNB9LB70, RNC_CHLSY
B0B7L3, RNC_CHLT2Q3KM65, RNC_CHLTAB0BBS8, RNC_CHLTB
Q8KAN7, RNC_CHLTEO84299, RNC_CHLTRQ7NWC4, RNC_CHRVO
Q97IA4, RNC_CLOABA6LSM2, RNC_CLOB8B2V4D6, RNC_CLOBA
B2TJ22, RNC_CLOBBB9E1G8, RNC_CLOK1A5N807, RNC_CLOK5
Q8XJN8, RNC_CLOPEQ895M9, RNC_CLOTEQ47WP5, RNC_COLP3
Q6NGH3, RNC_CORDIQ8FP16, RNC_COREFQ8NNV6, RNC_CORGL
Q4JUY7, RNC_CORJKB6J4J9, RNC_COXB1B6IYZ9, RNC_COXB2
A9KFA0, RNC_COXBNA9N942, RNC_COXBRP51837, RNC_COXBU
Q1LKN1, RNC_CUPMCQ0K8N3, RNC_CUPNHQ46Z18, RNC_CUPPJ
B3R1Z9, RNC_CUPTRQ47EF7, RNC_DECARQ3Z7Q8, RNC_DEHM1
Q3ZXY9, RNC_DEHMCA9BNJ5, RNC_DELASQ6ANV0, RNC_DESPS
A4J683, RNC_DESRMA8LLD9, RNC_DINSHA7ZQ11, RNC_ECO24
B7UH07, RNC_ECO27B7MIQ2, RNC_ECO45B7LDG0, RNC_ECO55
P0A7Y2, RNC_ECO57B5Z141, RNC_ECO5EB7NRM0, RNC_ECO7I
B7MYJ8, RNC_ECO81B7M8I0, RNC_ECO8AC4ZYJ0, RNC_ECOBW
B1XB41, RNC_ECODHA8A377, RNC_ECOHSA1AE97, RNC_ECOK1
Q0TES1, RNC_ECOL5P0A7Y1, RNC_ECOL6B1IVR0, RNC_ECOLC
P0A7Y0, RNC_ECOLIB7N6F5, RNC_ECOLUB6I5E1, RNC_ECOSE
B1LP80, RNC_ECOSMQ1R8G6, RNC_ECOUTC5B8Y2, RNC_EDWI9
Q3YQX7, RNC_EHRCJQ2GFE4, RNC_EHRCRQ5FGH0, RNC_EHRRG
Q5HA74, RNC_EHRRWA4WDD8, RNC_ENT38Q82ZG1, RNC_ENTFA
B2VI46, RNC_ERWT9B7LUZ7, RNC_ESCF3A6GW45, RNC_FLAPJ
B0TXH8, RNC_FRAP2Q14G66, RNC_FRAT1A7NAR0, RNC_FRATF
Q2A4N2, RNC_FRATHB2SFY4, RNC_FRATMA0Q7W6, RNC_FRATN
Q0BN07, RNC_FRATOQ5NER3, RNC_FRATTA4IWK9, RNC_FRATW
Q6GZP5, RNC_FRG3GQ8RGX3, RNC_FUSNNQ5L0Q3, RNC_GEOKA
Q39T82, RNC_GEOMGQ74AX1, RNC_GEOSLC5D8T6, RNC_GEOSW
A4IM67, RNC_GEOTNB8F3C7, RNC_GLAP5Q7NH89, RNC_GLOVI
Q7VL75, RNC_HAEDUQ4QPN0, RNC_HAEI8A5UBC4, RNC_HAEIE
A5UFI8, RNC_HAEIGP44441, RNC_HAEINQ2SL32, RNC_HAHCH
Q9KA05, RNC_HALH5C4K3Z3, RNC_HAMD5Q17XJ6, RNC_HELAH
Q7VIA9, RNC_HELHPB0TGW4, RNC_HELMIB6JLQ0, RNC_HELP2
B5Z735, RNC_HELPGQ9ZLH2, RNC_HELPJB2UTG4, RNC_HELPS
P56118, RNC_HELPYB0USS1, RNC_HISS2Q9NRR4, RNC_HUMAN
B4U7T8, RNC_HYDS0Q5R106, RNC_IDILOQ196V9, RNC_IIV3
O55748, RNC_IIV6Q28V23, RNC_JANSCB5XNH0, RNC_KLEP3
A6TCI1, RNC_KLEP7Q5FJJ7, RNC_LACACQ74IP8, RNC_LACJO
Q9CHD0, RNC_LACLAA2RLZ8, RNC_LACLMQ030F9, RNC_LACLS
Q88WK0, RNC_LACPLQ38XR8, RNC_LATSSQ5X446, RNC_LEGPA
A5ID21, RNC_LEGPCQ5ZUD5, RNC_LEGPHQ5WVI4, RNC_LEGPL
Q6AFJ4, RNC_LEIXXQ04R64, RNC_LEPBJQ053L4, RNC_LEPBL
Q75FW5, RNC_LEPICQ8EXX3, RNC_LEPINB1N016, RNC_LEUCK
Q03VW5, RNC_LEUMMQ1WUA0, RNC_LIGS1B2GD42, RNC_LIMF3
A5VKP2, RNC_LIMRDB2G826, RNC_LIMRJQ92AK3, RNC_LISIN
C1KWA4, RNC_LISMCQ71YL2, RNC_LISMFB8DDU8, RNC_LISMH
Q8Y691, RNC_LISMOA0AJR0, RNC_LISW6A0L633, RNC_MAGMM
Q65VN5, RNC_MANSMA6VUP6, RNC_MARMSQ6F1N5, RNC_MESFL
Q608M7, RNC_METCAB8EK13, RNC_METSBQ5UQT7, RNC_MIMIV
Q2RJX2, RNC_MOOTAQ5HZJ0, RNC_MOUSEP66667, RNC_MYCBO
Q2SRZ8, RNC_MYCCTQ7NAZ2, RNC_MYCGAP47607, RNC_MYCGE
D3FI09, RNC_MYCGFD3FH24, RNC_MYCGHO69469, RNC_MYCLE
Q6KHN3, RNC_MYCM1Q6MTC9, RNC_MYCMSQ73VL8, RNC_MYCPA
E1QCT1, RNC_MYCPBP75233, RNC_MYCPNA0QV20, RNC_MYCS2
Q4A589, RNC_MYCS5P9WH02, RNC_MYCTOP9WH03, RNC_MYCTU
Q1D5X9, RNC_MYXXDB2A2N1, RNC_NATTJQ5F9X7, RNC_NEIG1
B4RJT7, RNC_NEIG2C9X0M5, RNC_NEIM8Q9JVD3, RNC_NEIMA
Q9K0C8, RNC_NEIMBQ0AF70, RNC_NITECQ820I0, RNC_NITEU
Q3J8D5, RNC_NITOCA6Q1H0, RNC_NITSBQ72C44, RNC_NITV2
B8DPB3, RNC_NITV9Q3SRB3, RNC_NITWNQ5YS08, RNC_NOCFA
Q8ER05, RNC_OCEIHQ04GL2, RNC_OENOBQ310Z1, RNC_OLEA2
Q6YPW7, RNC_ONYPED4GKM1, RNC_PANAMQ6MEK1, RNC_PARUW
P57805, RNC_PASMUQ6D219, RNC_PECASC6DC00, RNC_PECCP
Q03FX0, RNC_PEDPAA5D1H6, RNC_PELTSQ4FLS9, RNC_PELUB
B4RCU4, RNC_PHEZHQ7N1X5, RNC_PHOLLQ6LMS2, RNC_PHOPR
A6KZ76, RNC_PHOV8B3R075, RNC_PHYMTG3XCR8, RNC_PROMA
B4F047, RNC_PROMHQ48EV3, RNC_PSE14A6VAK6, RNC_PSEA7
B7UYX2, RNC_PSEA8Q02HS2, RNC_PSEABQ9XCX9, RNC_PSEAE
Q1I5V8, RNC_PSEE4Q4KHT1, RNC_PSEF5C3K6Y7, RNC_PSEFS
A8F397, RNC_PSELTA4XSC4, RNC_PSEMYA5W8F2, RNC_PSEP1
Q3KHL9, RNC_PSEPFB0KV27, RNC_PSEPGQ88MY5, RNC_PSEPK
B1J4E0, RNC_PSEPWQ87XG1, RNC_PSESMQ3IDL2, RNC_PSET1
Q4ZPE1, RNC_PSEU2Q4FUV6, RNC_PSYA2A1SSM8, RNC_PSYIN
Q8Y0I1, RNC_RALN1B2U981, RNC_RALPJB3PUN8, RNC_RHIE6
Q2KAE3, RNC_RHIECQ1MJ54, RNC_RHIJ3Q985A6, RNC_RHILO
B5ZW73, RNC_RHILWQ92R47, RNC_RHIMEB9JC73, RNC_RHIR8
Q7UGZ7, RNC_RHOBAQ52698, RNC_RHOCAQ6N6C1, RNC_RHOPA
C3PMF3, RNC_RICAEA8GM79, RNC_RICAHA8GYE2, RNC_RICB8
Q1RHA2, RNC_RICBRA8EXI3, RNC_RICCKQ92JB0, RNC_RICCN
Q4UKA8, RNC_RICFEA8F0M2, RNC_RICM5Q9ZE31, RNC_RICPR
C4K1R3, RNC_RICPUB0BW84, RNC_RICROA8GQT8, RNC_RICRS
Q68XY5, RNC_RICTYA7NGC5, RNC_ROSCSQ16AI6, RNC_ROSDO
G2SYN4, RNC_ROSHAA5V230, RNC_ROSS1Q5LNK5, RNC_RUEPO
Q57LD0, RNC_SALCHB5QTU8, RNC_SALEPB5RD49, RNC_SALG2
Q5PIG5, RNC_SALPAB5BAT0, RNC_SALPKQ8Z4K4, RNC_SALTI
Q56056, RNC_SALTYA8GI25, RNC_SERP5A1S3Y1, RNC_SHEAM
B8EBQ2, RNC_SHEB2A3D1V6, RNC_SHEB5A6WKQ7, RNC_SHEB8
A9L5N6, RNC_SHEB9Q12KI1, RNC_SHEDOQ07YZ6, RNC_SHEFN
B0TIV7, RNC_SHEHHA3QBS7, RNC_SHELPQ8EH81, RNC_SHEON
A8H1C7, RNC_SHEPAA4Y4K4, RNC_SHEPCB8CQJ5, RNC_SHEPW
A0KZN2, RNC_SHESAA8FSD6, RNC_SHESHQ0HG98, RNC_SHESM
Q0HSJ1, RNC_SHESRA1RMC7, RNC_SHESWB1KI57, RNC_SHEWM
B2TXY0, RNC_SHIB3Q31XS0, RNC_SHIBSQ32CV4, RNC_SHIDS
Q0T1T8, RNC_SHIF8P0A7Y3, RNC_SHIFLQ3YYU9, RNC_SHISS
Q5WFM6, RNC_SHOC1C3M8S4, RNC_SINFNA6U7A8, RNC_SINMW
Q2NS13, RNC_SODGMQ027L3, RNC_SOLUEQ1GTU3, RNC_SPHAL
Q53844, RNC_SPICIA7X1J9, RNC_STAA1A6U152, RNC_STAA2
Q2FHK5, RNC_STAA3Q2FZ50, RNC_STAA8A5ISB8, RNC_STAA9
Q2YXI3, RNC_STAABQ5HGJ9, RNC_STAACA6QGD3, RNC_STAAE
Q931T1, RNC_STAAMP66668, RNC_STAANQ6GHK2, RNC_STAAR
Q6G9Y0, RNC_STAASA8Z3R9, RNC_STAATP66669, RNC_STAAW
B9DPJ2, RNC_STACTQ5HPV8, RNC_STAEQQ8CPI1, RNC_STAES
Q4L5T5, RNC_STAHJQ49X17, RNC_STAS1Q3K1Y2, RNC_STRA1
Q8E680, RNC_STRA3Q8E0K7, RNC_STRA5Q82JT9, RNC_STRAW
Q9ZBQ7, RNC_STRCOC0M8Y3, RNC_STRE4A8AWC2, RNC_STRGC
Q8DT66, RNC_STRMUP66670, RNC_STRP1Q04K72, RNC_STRP2
P0DF14, RNC_STRP3B5E4Y2, RNC_STRP4Q5XDA6, RNC_STRP6
C1C7M6, RNC_STRP7P66672, RNC_STRP8Q1JCZ9, RNC_STRPB
Q1JMX4, RNC_STRPCQ1JI19, RNC_STRPDQ1J7V3, RNC_STRPF
A2RFW8, RNC_STRPGB1IC43, RNC_STRPIB8ZJR8, RNC_STRPJ
Q48UR6, RNC_STRPMQ97QG6, RNC_STRPNP0DF15, RNC_STRPQ
B2IPN5, RNC_STRPSB5XKB7, RNC_STRPZQ8DPJ8, RNC_STRR6
C0MCR4, RNC_STRS7A3CP46, RNC_STRSVQ5LZ68, RNC_STRT1
Q5M3S3, RNC_STRT2Q03K17, RNC_STRTDB9DRH1, RNC_STRU0
C1CEK4, RNC_STRZJC1CKY7, RNC_STRZPC1CR56, RNC_STRZT
A6QCJ0, RNC_SULNBQ67PF5, RNC_SYMTHQ3A4Q8, RNC_SYNC1
A0LGM1, RNC_SYNFMQ0AYW0, RNC_SYNWWQ47S78, RNC_THEFY
Q9X0I6, RNC_THEMAB9K9K8, RNC_THENNA5IN74, RNC_THEP1
B1LCY9, RNC_THESQQ3SH50, RNC_THIDAQ73NX5, RNC_TREDE
O83787, RNC_TREPAB2S448, RNC_TREPSF2NV13, RNC_TRES6
Q83I82, RNC_TROW8Q83FY2, RNC_TROWTQ9PQT8, RNC_UREPA
C5CSF5, RNC_VARPSA1WMW1, RNC_VEREIB7VK79, RNC_VIBA3
A7MZA8, RNC_VIBC1A5F5H8, RNC_VIBC3Q9KPB2, RNC_VIBCH
C3LR04, RNC_VIBCMQ87LN9, RNC_VIBPAQ8DC76, RNC_VIBVU
Q7MHN8, RNC_VIBVYQ8D305, RNC_WIGBRQ73FT3, RNC_WOLPM
B3CMS0, RNC_WOLPPQ7M840, RNC_WOLSUQ5GTI3, RNC_WOLTR
C0R4Q8, RNC_WOLWRQ8PMV0, RNC_XANACQ4USF7, RNC_XANC8
Q8PB52, RNC_XANCPQ3BVV6, RNC_XANE5Q5H1R2, RNC_XANOR
B2I604, RNC_XYLF2Q9PB98, RNC_XYLFAB0U3D8, RNC_XYLFM
Q87C06, RNC_XYLFTA1JKK3, RNC_YERE8A7FFT9, RNC_YERP3
Q1C555, RNC_YERPAQ8ZD72, RNC_YERPEA9R402, RNC_YERPG
Q1CKE4, RNC_YERPNA4TKX8, RNC_YERPPQ667V1, RNC_YERPS
D5BDP9, RNC_ZUNPSQ9Z5U2, RNC_ZYMMOQ02555, RNT1_YEAST

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All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.1.26.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.1.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.-.-.-