ID 3.1.3.36 DE phosphoinositide 5-phosphatase. AN diphosphoinositide phosphatase. AN inositol 1,4,5-triphosphate 5-phosphomonoesterase. AN inositol triphosphate 5-phosphomonoesterase. AN IP3 phosphatase. AN phosphatidylinositol 4,5-bisphosphate phosphatase. AN phosphatidylinositol-bisphosphatase. AN phosphatidyl-inositol-bisphosphate phosphatase. AN phosphatidyl-myo-inositol-4,5-bisphosphate phosphatase. AN polyphosphoinositol lipid 5-phosphatase. AN PtdIns(4,5)P2 phosphatase. AN triphosphoinositide phosphatase. AN triphosphoinositide phosphomonoesterase. AN type II inositol-1,4,5-trisphosphate 5-phosphatase. AN type II inositol polyphosphate 5-phosphatase. CA a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + CA H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + CA phosphate. CC -!- These enzymes can also remove the 5-phosphate from Ins(1,4,5)P3 CC and/or Ins(1,3,4,5)P4. CC -!- They are a diverse family of enzymes, with differing abilities to CC catalyze two or more of the four reactions listed. CC -!- They are thought to use inositol lipids rather than inositol CC phosphates as substrates in vivo. CC -!- All of them can use either or both of PtdIns(4,5)P2 and CC PtdIns(3,4,5)P3 as substrates; this is the main property that CC distinguishes them from EC 3.1.3.56. DR Q92562, FIG4_HUMAN ; Q91WF7, FIG4_MOUSE ; P32019, I5P2_HUMAN ; DR Q8K337, I5P2_MOUSE ; P40559, INP51_YEAST; P50942, INP52_YEAST; DR Q12271, INP53_YEAST; Q08227, INP54_YEAST; Q9VTW2, INP5E_DROME; DR Q9NRR6, INP5E_HUMAN; Q9JII1, INP5E_MOUSE; A0FI79, INP5E_PANTR; DR Q9WVR1, INP5E_RAT ; Q9BT40, INP5K_HUMAN; Q8C5L6, INP5K_MOUSE; DR Q8H0Z6, IP5P3_ARATH; Q9LR47, IP5P6_ARATH; Q0WQ41, IP5P7_ARATH; DR Q9SIS4, IP5P9_ARATH; Q5EAF2, IP5PB_ARATH; Q9SKB7, IP5PE_ARATH; DR Q84W55, IP5PF_ARATH; Q01968, OCRL_HUMAN ; Q6NVF0, OCRL_MOUSE ; DR D3ZGS3, OCRL_RAT ; Q15735, PI5PA_HUMAN; P59644, PI5PA_MOUSE; DR Q9JMC1, PI5PA_RAT ; Q92835, SHIP1_HUMAN; Q9ES52, SHIP1_MOUSE; DR P97573, SHIP1_RAT ; Q6P4S2, SHIP1_XENLA; O43001, SYJ1_SCHPO ; DR Q9USQ6, SYJ2_SCHPO ; O18964, SYNJ1_BOVIN; O43426, SYNJ1_HUMAN; DR Q8CHC4, SYNJ1_MOUSE; Q62910, SYNJ1_RAT ; O15056, SYNJ2_HUMAN; DR Q9D2G5, SYNJ2_MOUSE; O55207, SYNJ2_RAT ; G5ECL2, SYNJ_CAEEL ; //