ID   3.1.3.36
DE   phosphoinositide 5-phosphatase.
AN   diphosphoinositide phosphatase.
AN   inositol 1,4,5-triphosphate 5-phosphomonoesterase.
AN   inositol triphosphate 5-phosphomonoesterase.
AN   IP3 phosphatase.
AN   phosphatidylinositol 4,5-bisphosphate phosphatase.
AN   phosphatidylinositol-bisphosphatase.
AN   phosphatidyl-inositol-bisphosphate phosphatase.
AN   phosphatidyl-myo-inositol-4,5-bisphosphate phosphatase.
AN   polyphosphoinositol lipid 5-phosphatase.
AN   PtdIns(4,5)P2 phosphatase.
AN   triphosphoinositide phosphatase.
AN   triphosphoinositide phosphomonoesterase.
AN   type II inositol-1,4,5-trisphosphate 5-phosphatase.
AN   type II inositol polyphosphate 5-phosphatase.
CA   a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) +
CA   H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) +
CA   phosphate.
CC   -!- These enzymes can also remove the 5-phosphate from Ins(1,4,5)P3
CC       and/or Ins(1,3,4,5)P4.
CC   -!- They are a diverse family of enzymes, with differing abilities to
CC       catalyze two or more of the four reactions listed.
CC   -!- They are thought to use inositol lipids rather than inositol
CC       phosphates as substrates in vivo.
CC   -!- All of them can use either or both of PtdIns(4,5)P2 and
CC       PtdIns(3,4,5)P3 as substrates; this is the main property that
CC       distinguishes them from EC 3.1.3.56.
DR   Q92562, FIG4_HUMAN ;  Q91WF7, FIG4_MOUSE ;  P32019, I5P2_HUMAN ;
DR   Q8K337, I5P2_MOUSE ;  P40559, INP51_YEAST;  P50942, INP52_YEAST;
DR   Q12271, INP53_YEAST;  Q08227, INP54_YEAST;  Q9VTW2, INP5E_DROME;
DR   Q9NRR6, INP5E_HUMAN;  Q9JII1, INP5E_MOUSE;  A0FI79, INP5E_PANTR;
DR   Q9WVR1, INP5E_RAT  ;  Q9BT40, INP5K_HUMAN;  Q8C5L6, INP5K_MOUSE;
DR   Q8H0Z6, IP5P3_ARATH;  Q9LR47, IP5P6_ARATH;  Q0WQ41, IP5P7_ARATH;
DR   Q9SIS4, IP5P9_ARATH;  Q5EAF2, IP5PB_ARATH;  Q9SKB7, IP5PE_ARATH;
DR   Q84W55, IP5PF_ARATH;  Q01968, OCRL_HUMAN ;  Q6NVF0, OCRL_MOUSE ;
DR   D3ZGS3, OCRL_RAT   ;  Q15735, PI5PA_HUMAN;  P59644, PI5PA_MOUSE;
DR   Q9JMC1, PI5PA_RAT  ;  Q92835, SHIP1_HUMAN;  Q9ES52, SHIP1_MOUSE;
DR   P97573, SHIP1_RAT  ;  Q6P4S2, SHIP1_XENLA;  O43001, SYJ1_SCHPO ;
DR   Q9USQ6, SYJ2_SCHPO ;  O18964, SYNJ1_BOVIN;  O43426, SYNJ1_HUMAN;
DR   Q8CHC4, SYNJ1_MOUSE;  Q62910, SYNJ1_RAT  ;  O15056, SYNJ2_HUMAN;
DR   Q9D2G5, SYNJ2_MOUSE;  O55207, SYNJ2_RAT  ;  G5ECL2, SYNJ_CAEEL ;
//