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ENZYME

ENZYME entry: EC 3.1.3.4

PURL: https://purl.expasy.org/enzyme/EC/3.1.3.4
Accepted Name
phosphatidate phosphatase
Alternative Name(s)
lipin
phosphatic acid phosphatase
phosphatic acid phosphohydrolase
phosphatidic acid phosphatase
Reaction catalysed
a 1,2-diacyl-sn-glycero-3-phosphate + H2O = a 1,2-diacyl-sn-glycerol + phosphate
Comment(s)
  • This enzyme catalyzes the Mg(2+)-dependent dephosphorylation of a 1,2-diacylglycerol-3-phosphate, yielding a 1,2-diacyl-sn-glycerol (DAG), the substrate for de novo lipid synthesis via the Kennedy pathway and for the synthesis of triacylglycerol.
  • In lipid signaling, the enzyme generates a pool of DAG to be used for protein kinase C activation.
  • The mammalian enzymes are known as lipins.
Cross-references
BRENDA3.1.3.4
EC2PDB3.1.3.4
ExplorEnz3.1.3.4
KEGG Ligand Database for Enzyme Nomenclature3.1.3.4
IUBMB Enzyme Nomenclature3.1.3.4
MEDLINEFind literature relating to 3.1.3.4
MetaCyc3.1.3.4
Rhea expert-curated reactions3.1.3.4
UniProtKB/Swiss-Prot
P53933, APP1_YEASTQ9UUA6, DPP1_SCHPOQ05521, DPP1_YEAST
Q14693, LPIN1_HUMANQ91ZP3, LPIN1_MOUSEQ92539, LPIN2_HUMAN
Q99PI5, LPIN2_MOUSEQ9BQK8, LPIN3_HUMANQ99PI4, LPIN3_MOUSE
Q7TNN8, LPIN3_MUSSPQ04396, LPP1_YEASTQ9SF47, PAH1_ARATH
P32567, PAH1_YEASTQ9FMN2, PAH2_ARATHP0A925, PGPB_ECO57
P0A924, PGPB_ECOLIP44570, PGPB_HAEINP0A926, PGPB_SHIFL
O88956, PLPP1_CAVPOO14494, PLPP1_HUMANQ61469, PLPP1_MOUSE
P60588, PLPP1_PIGO08564, PLPP1_RATQ2HJ61, PLPP2_BOVIN
O43688, PLPP2_HUMANQ9DAX2, PLPP2_MOUSEQ8K593, PLPP2_RAT
Q3SZE3, PLPP3_BOVINO14495, PLPP3_HUMANQ99JY8, PLPP3_MOUSE
P97544, PLPP3_RATQ5VZY2, PLPP4_HUMANQ0VBU9, PLPP4_MOUSE
Q8NEB5, PLPP5_HUMANQ3UMZ3, PLPP5_MOUSEQ6GQ62, PLPP5_XENLA
Q9V576, WUN_DROME

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