- This enzyme catalyzes the Mg(2+)-dependent dephosphorylation of a
1,2-diacylglycerol-3-phosphate, yielding a 1,2-diacyl-sn-glycerol
(DAG), the substrate for de novo lipid synthesis via the Kennedy
pathway and for the synthesis of triacylglycerol.
- In lipid signaling, the enzyme generates a pool of DAG to be used for
protein kinase C activation.
- The mammalian enzymes are known as lipins.
|
| UniProtKB/Swiss-Prot |
| P53933, APP1_YEAST; | Q9UUA6, DPP1_SCHPO; | Q05521, DPP1_YEAST; |
| Q14693, LPIN1_HUMAN; | Q91ZP3, LPIN1_MOUSE; | Q92539, LPIN2_HUMAN; |
| Q99PI5, LPIN2_MOUSE; | Q9BQK8, LPIN3_HUMAN; | Q99PI4, LPIN3_MOUSE; |
| Q7TNN8, LPIN3_MUSSP; | Q04396, LPP1_YEAST; | Q9SF47, PAH1_ARATH; |
| P32567, PAH1_YEAST; | Q9FMN2, PAH2_ARATH; | P0A925, PGPB_ECO57; |
| P0A924, PGPB_ECOLI; | P44570, PGPB_HAEIN; | P0A926, PGPB_SHIFL; |
| O88956, PLPP1_CAVPO; | O14494, PLPP1_HUMAN; | Q61469, PLPP1_MOUSE; |
| P60588, PLPP1_PIG; | O08564, PLPP1_RAT; | Q2HJ61, PLPP2_BOVIN; |
| O43688, PLPP2_HUMAN; | Q9DAX2, PLPP2_MOUSE; | Q8K593, PLPP2_RAT; |
| Q3SZE3, PLPP3_BOVIN; | O14495, PLPP3_HUMAN; | Q99JY8, PLPP3_MOUSE; |
| P97544, PLPP3_RAT; | Q5VZY2, PLPP4_HUMAN; | Q0VBU9, PLPP4_MOUSE; |
| Q8NEB5, PLPP5_HUMAN; | Q3UMZ3, PLPP5_MOUSE; | Q6GQ62, PLPP5_XENLA; |
| Q29RT8, PLPR2_BOVIN; | Q96GM1, PLPR2_HUMAN; | Q8VCY8, PLPR2_MOUSE; |
| Q6W5G4, PLPR2_RAT; | Q6T4P5, PLPR3_HUMAN; | Q7TPB0, PLPR3_MOUSE; |
| Q7TMB0, PLPR3_RAT; | Q7Z2D5, PLPR4_HUMAN; | Q7TME0, PLPR4_MOUSE; |
| Q7TMB7, PLPR4_RAT; | Q9V576, WUN_DROME; |
|