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ENZYME entry: EC 3.1.3.66

Accepted Name
phosphatidylinositol-3,4-bisphosphate 4-phosphatase.
Alternative Name(s)
D-myo-inositol-3,4-bisphosphate 4-phosphohydrolase.
inositol-3,4-bisphosphate 4-phosphatase.
inositol polyphosphate 4-phosphatase.
inositol polyphosphate 4-phosphatase type II.
phosphoinositide 4-phosphatase.
Reaction catalysed
a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + H2O <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + phosphate
Comment(s)
  • Magnesium-independent.
  • This enzyme still works when the 2,3-bis(acyloxy)propyl group is removed, i.e., it hydrolyzes Ins(1,3,4)P3 to Ins(1,3)P2.
  • It also converts Ins(3,4)P2 into Ins-3-P.
Cross-references
BRENDA3.1.3.66
EC2PDB3.1.3.66
ExplorEnz3.1.3.66
PRIAM enzyme-specific profiles3.1.3.66
KEGG Ligand Database for Enzyme Nomenclature3.1.3.66
IUBMB Enzyme Nomenclature3.1.3.66
IntEnz3.1.3.66
MEDLINEFind literature relating to 3.1.3.66
MetaCyc3.1.3.66
Rhea expert-curated reactions3.1.3.66
UniProtKB/Swiss-Prot
Q96PE3, INP4A_HUMAN;  Q9EPW0, INP4A_MOUSE;  Q62784, INP4A_RAT;  
O15327, INP4B_HUMAN;  Q4R4D7, INP4B_MACFA;  Q6P1Y8, INP4B_MOUSE;  
Q5RA60, INP4B_PONAB;  Q9QWG5, INP4B_RAT;  

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