| Accepted Name |
|---|
| phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase.
|
| Alternative Name(s) |
|---|
| phosphatidylinositol-3,4,5-trisphosphate 3-phosphohydrolase. |
| Reaction catalysed |
|---|
| a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + phosphate |
| Comment(s) |
|---|
- Does not dephosphorylate inositol 4,5-bisphosphate.
- This enzyme still works when the 2,3-bis(acyloxy)propyl group is
removed, i.e., it hydrolyzes Ins(1,3,4,5)P4 to Ins(1,4,5)P3.
|
| Cross-references |
|---|
| BRENDA | 3.1.3.67 |
| EC2PDB | 3.1.3.67 |
| ExplorEnz | 3.1.3.67 |
| PRIAM enzyme-specific profiles | 3.1.3.67 |
| KEGG Ligand Database for Enzyme Nomenclature | 3.1.3.67 |
| IUBMB Enzyme Nomenclature | 3.1.3.67 |
| IntEnz | 3.1.3.67 |
| MEDLINE | Find literature relating to 3.1.3.67 |
| MetaCyc | 3.1.3.67 |
| Rhea expert-curated reactions | 3.1.3.67 |
| UniProtKB/Swiss-Prot |
| Q54JL7, CNRN_DICDI; | Q9FLZ5, PTEN1_ARATH; | G5EE01, PTEN_CAEEL; |
| P60483, PTEN_CANLF; | Q8T9S7, PTEN_DICDI; | P60484, PTEN_HUMAN; |
| O08586, PTEN_MOUSE; | O54857, PTEN_RAT; | O94526, PTEN_SCHPO; |
| Q9PUT6, PTEN_XENLA; | Q9LT75, PTN2A_ARATH; | Q8H106, PTN2B_ARATH; |
| P53916, TEP1_YEAST; | Q6XPS3, TPTE2_HUMAN; | Q4R6N0, TPTE2_MACFA; |
|