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ENZYME entry: EC 3.1.3.67

Accepted Name
Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase.
Alternative Name(s)
Phosphatidylinositol-3,4,5-trisphosphate 3-phosphohydrolase.
Reaction catalysed
Phosphatidylinositol 3,4,5-trisphosphate + H(2)O <=> phosphatidylinositol 4,5-bisphosphate + phosphate
Cofactor(s)
Mg(2+).
Comment(s)
  • Does not dephosphorylate inositol 4,5-bisphosphate.
  • This enzyme still works when the 2,3-bis(acyloxy)propyl group is removed, i.e., it hydrolyzes Ins(1,3,4,5)P(4) to Ins(1,4,5)P(3).
Cross-references
BRENDA3.1.3.67
EC2PDB3.1.3.67
ExplorEnz3.1.3.67
PRIAM enzyme-specific profiles3.1.3.67
KEGG Ligand Database for Enzyme Nomenclature3.1.3.67
IUBMB Enzyme Nomenclature3.1.3.67
IntEnz3.1.3.67
MEDLINEFind literature relating to 3.1.3.67
MetaCyc3.1.3.67
Rhea expert-curated reactions3.1.3.67
UniProtKB/Swiss-Prot
Q54JL7, CNRN_DICDI;  Q9FLZ5, PTEN1_ARATH;  G5EE01, PTEN_CAEEL;  
P60483, PTEN_CANLF;  Q8T9S7, PTEN_DICDI;  P60484, PTEN_HUMAN;  
O08586, PTEN_MOUSE;  O94526, PTEN_SCHPO;  Q9PUT6, PTEN_XENLA;  
Q9LT75, PTN2A_ARATH;  Q8H106, PTN2B_ARATH;  P53916, TEP1_YEAST;  
Q6XPS3, TPTE2_HUMAN;  Q4R6N0, TPTE2_MACFA;  

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