ENZYME entry: EC 3.1.3.67
Accepted Name |
Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase.
|
Alternative Name(s) |
Phosphatidylinositol-3,4,5-trisphosphate 3-phosphohydrolase. |
Reaction catalysed |
Phosphatidylinositol 3,4,5-trisphosphate + H(2)O <=> phosphatidylinositol 4,5-bisphosphate + phosphate |
Cofactor(s) |
Mg(2+).
|
Comment(s) |
- Does not dephosphorylate inositol 4,5-bisphosphate.
- This enzyme still works when the 2,3-bis(acyloxy)propyl group is
removed, i.e., it hydrolyzes Ins(1,3,4,5)P(4) to Ins(1,4,5)P(3).
|
Cross-references |
BRENDA | 3.1.3.67 |
EC2PDB | 3.1.3.67 |
ExplorEnz | 3.1.3.67 |
PRIAM enzyme-specific profiles | 3.1.3.67 |
KEGG Ligand Database for Enzyme Nomenclature | 3.1.3.67 |
IUBMB Enzyme Nomenclature | 3.1.3.67 |
IntEnz | 3.1.3.67 |
MEDLINE | Find literature relating to 3.1.3.67 |
MetaCyc | 3.1.3.67 |
UniProtKB/Swiss-Prot |
Q54JL7, CNRN_DICDI; | Q9FLZ5, PTEN1_ARATH; | G5EE01, PTEN_CAEEL; |
P60483, PTEN_CANLF; | Q8T9S7, PTEN_DICDI; | P60484, PTEN_HUMAN; |
O08586, PTEN_MOUSE; | O94526, PTEN_SCHPO; | Q9PUT6, PTEN_XENLA; |
Q9LT75, PTN2A_ARATH; | Q8H106, PTN2B_ARATH; | P53916, TEP1_YEAST; |
Q6XPS3, TPTE2_HUMAN; | Q4R6N0, TPTE2_MACFA; |
|
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UniProtKB/Swiss-Prot entries corresponding to 3.1.3.-
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