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ENZYME entry: EC 3.1.3.71

Accepted Name
2-phosphosulfolactate phosphatase.
Alternative Name(s)
(2R)-phosphosulfolactate phosphohydrolase.
ComB phosphatase.
Reaction catalysed
(2R)-2-phospho-3-sulfolactate + H(2)O <=> (2R)-3-sulfolactate + phosphate
Cofactor(s)
Mg(2+).
Comment(s)
  • The enzyme from Methanococcus jannaschii acts on both stereoisoimers of the substrate and also hydrolyzes a number of phosphate monoesters of (S)-2-hydroxycarboxylic acids, including 2-phosphomalate, 2-phospholactate and 2-phosphoglycolate.
  • This enzyme can also hydrolyze phosphate monoesters of (R)-2- hydroxycarboxylic acids such as (S)-2-phospho-3-sulfolactate and (R)- 2-phosphomalate, which, presumably, bind to the enzyme in opposite orientations.
Cross-references
BRENDA3.1.3.71
EC2PDB3.1.3.71
ExplorEnz3.1.3.71
PRIAM enzyme-specific profiles3.1.3.71
KEGG Ligand Database for Enzyme Nomenclature3.1.3.71
IUBMB Enzyme Nomenclature3.1.3.71
IntEnz3.1.3.71
MEDLINEFind literature relating to 3.1.3.71
MetaCyc3.1.3.71
UniProtKB/Swiss-Prot
O06738, COMB_BACSU;  Q8R8M3, COMB_CALS4;  A4XFZ6, COMB_CALS8;  
Q3AD96, COMB_CARHZ;  Q97E82, COMB_CLOAB;  A7FPH4, COMB_CLOB1;  
C3KWA9, COMB_CLOB6;  A6LPF0, COMB_CLOB8;  B2UX99, COMB_CLOBA;  
B2THU3, COMB_CLOBB;  C1FNF9, COMB_CLOBJ;  B1IH09, COMB_CLOBK;  
A7GJE7, COMB_CLOBL;  B1KTF5, COMB_CLOBM;  B9DY39, COMB_CLOK1;  
A5N4H7, COMB_CLOK5;  A0Q380, COMB_CLONN;  Q0TM95, COMB_CLOP1;  
Q8XHC9, COMB_CLOPE;  Q0SPZ8, COMB_CLOPS;  Q899J5, COMB_CLOTE;  
B8HW27, COMB_CYAP4;  C1D1F5, COMB_DEIDV;  Q1IYS0, COMB_DEIGD;  
Q9RUI6, COMB_DEIRA;  B7K825, COMB_GLOC7;  Q7NCK4, COMB_GLOVI;  
Q58540, COMB_METJA;  O27250, COMB_METTH;  B0JV88, COMB_MICAN;  
B2IVU1, COMB_NOSP7;  Q8YTZ5, COMB_NOSS1;  A2C172, COMB_PROM1;  
A2CAX3, COMB_PROM3;  Q7VBP6, COMB_PROMA;  Q7V8F6, COMB_PROMM;  
Q46LT5, COMB_PROMT;  A8F5X7, COMB_PSELT;  B7JUJ9, COMB_RIPO1;  
Q9F3E6, COMB_STRCO;  Q67NP7, COMB_SYMTH;  Q2JWJ9, COMB_SYNJA;  
Q2JPJ7, COMB_SYNJB;  B1XQ41, COMB_SYNP2;  A5GKJ5, COMB_SYNPW;  
Q7U7H6, COMB_SYNPX;  A5GT49, COMB_SYNR3;  Q0I9X0, COMB_SYNS3;  
Q3AXB9, COMB_SYNS9;  Q3AKJ4, COMB_SYNSC;  P73849, COMB_SYNY3;  
Q9HIA9, COMB_THEAC;  Q8DLS5, COMB_THEEB;  Q9WZQ4, COMB_THEMA;  
A5IIY7, COMB_THEP1;  Q72IQ9, COMB_THET2;  Q5SID6, COMB_THET8;  
Q97CK6, COMB_THEVO;  Q116L2, COMB_TRIEI;  Q3MFW5, COMB_TRIV2;  

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