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|a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + phosphate|
- This enzyme hydrolyzes phosphatidylinositol-3,4,5-trisphosphate
(PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively
regulating the PI3K (phosphoinositide 3-kinase) pathways.
- The enzyme also shows activity toward PtdIns(1,3,4,5)P4.
- The enzyme is involved in several signal transduction pathways in the
immune system leading to an adverse range of effects.
- Formerly EC 3.1.3.n1.
|PRIAM enzyme-specific profiles||126.96.36.199|
|KEGG Ligand Database for Enzyme Nomenclature||188.8.131.52|
|IUBMB Enzyme Nomenclature||184.108.40.206|
|MEDLINE||Find literature relating to 220.127.116.11|
|Rhea expert-curated reactions||18.104.22.168|
|Q92562, FIG4_HUMAN; ||Q91WF7, FIG4_MOUSE; ||Q9NRR6, INP5E_HUMAN; |
|Q9JII1, INP5E_MOUSE; ||A0FI79, INP5E_PANTR; ||Q9WVR1, INP5E_RAT; |
|Q9BT40, INP5K_HUMAN; ||Q8C5L6, INP5K_MOUSE; ||Q8H0Z6, IP5P3_ARATH; |
|Q9LR47, IP5P6_ARATH; ||Q0WQ41, IP5P7_ARATH; ||Q9SIS4, IP5P9_ARATH; |
|Q5EAF2, IP5PB_ARATH; ||Q9SKB7, IP5PE_ARATH; ||Q84W55, IP5PF_ARATH; |
|Q01968, OCRL_HUMAN; ||Q6NVF0, OCRL_MOUSE; ||D3ZGS3, OCRL_RAT; |
|Q92835, SHIP1_HUMAN; ||Q9ES52, SHIP1_MOUSE; ||P97573, SHIP1_RAT; |
|Q6P4S2, SHIP1_XENLA; ||O15357, SHIP2_HUMAN; ||Q6P549, SHIP2_MOUSE; |
|D7PF45, SHIP2_PIG; ||Q9WVR3, SHIP2_RAT; ||Q2I6J1, SHP2A_DANRE; |
|Q2I6J0, SHP2B_DANRE; |