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ENZYME

ENZYME entry: EC 3.1.4.1

PURL: https://purl.expasy.org/enzyme/EC/3.1.4.1
Accepted Name
phosphodiesterase I
Alternative Name(s)
5'-exonuclease
5'-NPDase
5'NPDE
5'-nucleotide phosphodiesterase
5' nucleotide phosphodiesterase/alkaline phosphodiesterase I
5'-PDase
5'-PDE
5'-phosphodiesterase
alkaline phosphodiesterase
exonuclease I
nucleotide pyrophosphatase/phosphodiesterase I
oligonucleate 5'-nucleotidohydrolase
orthophosphoric diester phosphohydrolase
PDE I
phosphodiesterase
Reaction catalysed
Hydrolytically removes 5'-nucleotides successively from the 3'-hydroxy termini of 3'-hydroxy-terminated oligonucleotides
Comment(s)
  • Hydrolyzes both ribonucleotides and deoxyribonucleotides.
  • Has low activity toward polynucleotides.
  • A 3'-phosphate terminus on the substrate inhibits hydrolysis.
Cross-references
BRENDA3.1.4.1
EC2PDB3.1.4.1
ExplorEnz3.1.4.1
KEGG Ligand Database for Enzyme Nomenclature3.1.4.1
IUBMB Enzyme Nomenclature3.1.4.1
MEDLINEFind literature relating to 3.1.4.1
MetaCyc3.1.4.1
Rhea expert-curated reactions3.1.4.1
UniProtKB/Swiss-Prot
P22413, ENPP1_HUMANP06802, ENPP1_MOUSEQ924C3, ENPP1_RAT
P15396, ENPP3_BOVINO14638, ENPP3_HUMANQ6DYE8, ENPP3_MOUSE
Q5R5M5, ENPP3_PONABP97675, ENPP3_RATD2HNY3, FAN1_AILME
Q5XVJ4, FAN1_ARATHA8WZU5, FAN1_CAEBRP90740, FAN1_CAEEL
Q1LWH4, FAN1_DANREQ55FW8, FAN1_DICDIQ9Y2M0, FAN1_HUMAN
Q69ZT1, FAN1_MOUSEQ5SNL7, FAN1_ORYSJQ9I2N0, FAN1_PSEAE
Q9Y804, FAN1_SCHPOP25353, NPP1_YEASTP39997, NPP2_YEAST

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.1.4.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.1.-.-
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