A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC 3.1.4.3

Accepted Name
Phospholipase C.
Alternative Name(s)
Clostridium oedematiens beta- and gamma-toxins.
Clostridium welchii alpha-toxin.
Lecithinase C.
Lipophosphodiesterase I.
Reaction catalysed
A phosphatidylcholine + H(2)O <=> 1,2-diacyl-sn-glycerol + phosphocholine
Cofactor(s)
Zn(2+).
Comment(s)
  • The bacterial enzyme also acts on sphingomyelin and phosphatidylinositol.
  • The enzyme from seminal plasma does not act on phosphatidylinositol.
Cross-references
PROSITEPDOC00357
BRENDA3.1.4.3
EC2PDB3.1.4.3
ExplorEnz3.1.4.3
PRIAM enzyme-specific profiles3.1.4.3
KEGG Ligand Database for Enzyme Nomenclature3.1.4.3
IUBMB Enzyme Nomenclature3.1.4.3
IntEnz3.1.4.3
MEDLINEFind literature relating to 3.1.4.3
MetaCyc3.1.4.3
UniProtKB/Swiss-Prot
Q9SRQ7, NPC4_ARATH;  Q9S816, NPC5_ARATH;  P9WIB4, PHLA_MYCTO;  
P9WIB5, PHLA_MYCTU;  P9WIB2, PHLB_MYCTO;  P9WIB3, PHLB_MYCTU;  
P0C216, PHLC1_CLOPE;  P09598, PHLC_BACCE;  P59026, PHLC_CLOHA;  
Q46150, PHLC_CLONO;  Q0TV31, PHLC_CLOP1;  Q9RF12, PHLC_CLOPF;  
P33378, PHLC_LISMO;  P9WIB0, PHLC_MYCTO;  P9WIB1, PHLC_MYCTU;  
Q8VUZ6, PHLC_PAESO;  P20419, PHLC_PARBF;  P06200, PHLC_PSEAE;  
Q2FWP1, PHLC_STAA8;  Q5HEI1, PHLC_STAAC;  P09978, PHLC_STAAU;  
P33376, PHLD_BACCE;  P0A5R9, PHLD_MYCBO;  P9WIA8, PHLD_MYCTO;  
P9WIA9, PHLD_MYCTU;  Q9RGS8, PHLN_BURPS;  P15713, PHLN_PSEAE;  

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All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.1.4.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.1.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.-.-.-