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ENZYME entry: EC 3.1.4.37

Accepted Name
2',3'-cyclic-nucleotide 3'-phosphodiesterase.
Alternative Name(s)
cyclic-CMP phosphodiesterase.
Reaction catalysed
a nucleoside 2',3'-cyclic phosphate + H2O <=> a nucleoside 2'-phosphate + H(+)
Comment(s)
  • The brain enzyme acts on 2',3'-cyclic AMP more rapidly than on the UMP or CMP derivatives.
  • An enzyme from liver acts on 2',3'-cyclic CMP more rapidly than on the purine derivatives; it also hydrolyzes the corresponding 3',5'-cyclic phosphates, more slowly.
  • This latter enzyme has been called cyclic-CMP phosphodiesterase.
Cross-references
BRENDA3.1.4.37
EC2PDB3.1.4.37
ExplorEnz3.1.4.37
PRIAM enzyme-specific profiles3.1.4.37
KEGG Ligand Database for Enzyme Nomenclature3.1.4.37
IUBMB Enzyme Nomenclature3.1.4.37
IntEnz3.1.4.37
MEDLINEFind literature relating to 3.1.4.37
MetaCyc3.1.4.37
Rhea expert-curated reactions3.1.4.37
UniProtKB/Swiss-Prot
P06623, CN37_BOVIN;  P09543, CN37_HUMAN;  P16330, CN37_MOUSE;  
Q5RFD0, CN37_PONAB;  P13233, CN37_RAT;  Q758H6, CPD1_ASHGO;  
Q59PZ7, CPD1_CANAL;  Q6FTX0, CPD1_CANGA;  Q6BGW3, CPD1_DEBHA;  
Q6CXV0, CPD1_KLULA;  Q7S724, CPD1_NEUCR;  Q0UME8, CPD1_PHANO;  
Q6CGD3, CPD1_YARLI;  P53314, CPD1_YEAST;  

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