ID   3.1.4.52
DE   Cyclic-guanylate-specific phosphodiesterase.
AN   C-di-GMP-specific phosphodiesterase.
AN   PDEA1.
AN   Phosphodiesterase A1.
CA   Cyclic di-3',5'-guanylate + H(2)O = 5'-phosphoguanylyl(3'->5')guanosine.
CF   Heme; Mg(2+); Mn(2+).
CC   -!- Inhibited by Ca(2+) and Zn(2+).
CC   -!- Linearizes cyclic di-3',5'-guanylate, the product of EC 2.7.7.65 and
CC       an allosteric activator of EC 2.4.1.12 rendering it inactive.
CC   -!- It is the balance between these two enzymes that determines the
CC       cellular level of cyclic di-3',5'-guanylate.
DR   Q9KVK6, CDGJ_VIBCH ;  Q9KVL2, CDPA_VIBCH ;  P76129, DOSP_ECOLI ;
DR   O51338, PDEA_BORBU ;  P23842, PDEA_ECOLI ;  P77473, PDEB_ECOLI ;
DR   Q8EJM6, PDEB_SHEON ;  P32701, PDEC_ECOLI ;  P76261, PDED_ECOLI ;
DR   P77172, PDEF_ECOLI ;  P75995, PDEG_ECOLI ;  P37646, PDEH_ECOLI ;
DR   P75800, PDEI_ECOLI ;  P37649, PDEK_ECOLI ;  P21514, PDEL_ECOLI ;
DR   P76446, PDEN_ECOLI ;  P77334, PDER_ECOLI ;
//