ID   3.1.4.52
DE   cyclic-guanylate-specific phosphodiesterase.
AN   c-di-GMP-specific phosphodiesterase.
AN   PDEA1.
AN   phosphodiesterase A1.
CA   3',3'-c-di-GMP + H2O = 5'-phosphoguanylyl(3'->5')guanosine + H(+).
CC   -!- Inhibited by Ca(2+) and Zn(2+).
CC   -!- Linearizes cyclic di-3',5'-guanylate, the product of EC 2.7.7.65 and
CC       an allosteric activator of EC 2.4.1.12 rendering it inactive.
CC   -!- It is the balance between these two enzymes that determines the
CC       cellular level of cyclic di-3',5'-guanylate.
DR   Q9KVK6, CDGJ_VIBCH ;  Q9KVL2, CDPA_VIBCH ;  Q9I0R8, CDPD3_PSEAE;
DR   P76129, DOSP_ECOLI ;  O51338, PDEA_BORBU ;  P23842, PDEA_ECOLI ;
DR   P77473, PDEB_ECOLI ;  Q8EJM6, PDEB_SHEON ;  P32701, PDEC_ECOLI ;
DR   P76261, PDED_ECOLI ;  P77172, PDEF_ECOLI ;  P75995, PDEG_ECOLI ;
DR   P37646, PDEH_ECOLI ;  P75800, PDEI_ECOLI ;  P37649, PDEK_ECOLI ;
DR   P21514, PDEL_ECOLI ;  P76446, PDEN_ECOLI ;  P77334, PDER_ECOLI ;
DR   Q9HX69, ROCR_PSEAE ;  Q87NI7, TPDA_VIBPA ;
//