ID   3.1.4.53
DE   3',5'-cyclic-AMP phosphodiesterase.
AN   cAMP-specific PDE.
AN   cAMP-specific phosphodiesterase.
CA   3',5'-cyclic AMP + H2O = AMP + H(+).
CC   -!- Specific for 3',5'-cAMP and does not hydrolyze other nucleoside
CC       3',5'-cyclic phosphates such as cGMP (cf. EC 3.1.4.17 and
CC       EC 3.1.4.35).
CC   -!- It is involved in modulation of the levels of cAMP, which is a
CC       mediator in the processes of cell transformation and proliferation.
CC   -!- Formerly EC 3.1.4.n1.
DR   D4P095, CNPD3_PSEAI;  P0AEW5, CPDA_ECO57 ;  P0AEW4, CPDA_ECOLI ;
DR   P44685, CPDA_HAEIN ;  Q8DEI1, CPDA_VIBVU ;  Q9VJ79, PDE11_DROME;
DR   Q9HCR9, PDE11_HUMAN;  P0C1Q2, PDE11_MOUSE;  Q8VID6, PDE11_RAT  ;
DR   Q1KKS3, PDE11_TAKRU;  P12019, PDE1_DICDI ;  Q23917, PDE2_DICDI ;
DR   P06776, PDE2_YEAST ;  O89085, PDE4A_CAVPO;  Q9W4T4, PDE4A_DROME;
DR   P27815, PDE4A_HUMAN;  O89084, PDE4A_MOUSE;  P54748, PDE4A_RAT  ;
DR   P12252, PDE4B_DROME;  Q07343, PDE4B_HUMAN;  P14646, PDE4B_RAT  ;
DR   Q9W4S9, PDE4C_DROME;  Q08493, PDE4C_HUMAN;  Q3UEI1, PDE4C_MOUSE;
DR   P14644, PDE4C_RAT  ;  Q08499, PDE4D_HUMAN;  Q01063, PDE4D_MOUSE;
DR   P14270, PDE4D_RAT  ;  Q8IRU4, PDE4E_DROME;  Q22000, PDE4_CAEEL ;
DR   Q86H13, PDE4_DICDI ;  Q8MM62, PDE6_DICDI ;  Q13946, PDE7A_HUMAN;
DR   P70453, PDE7A_MOUSE;  O08593, PDE7A_RAT  ;  Q9NP56, PDE7B_HUMAN;
DR   Q9QXQ1, PDE7B_MOUSE;  Q54HY0, PDE7_DICDI ;  O60658, PDE8A_HUMAN;
DR   O88502, PDE8A_MOUSE;  O95263, PDE8B_HUMAN;  E9Q4S1, PDE8B_MOUSE;
DR   Q6NNF2, PDE8_DROME ;  Q8I6Z7, PDEB_PLAF7 ;
//