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ENZYME

ENZYME entry: EC 3.1.4.54

Accepted Name
N-acetylphosphatidylethanolamine-hydrolyzing phospholipase D
Alternative Name(s)
anandamide-generating phospholipase D
N-acyl phosphatidylethanolamine phospholipase D
Reaction catalysed
H2O + N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine = a 1,2-diacyl-sn-glycero-3-phosphate + an N-acylethanolamine + H(+)
Comment(s)
  • This enzyme is involved in the biosynthesis of anandamide.
  • It does not hydrolyze phosphatidylcholine and phosphatidylethanolamine.
  • No transphosphatidation.
Cross-references
BRENDA3.1.4.54
EC2PDB3.1.4.54
ExplorEnz3.1.4.54
PRIAM enzyme-specific profiles3.1.4.54
KEGG Ligand Database for Enzyme Nomenclature3.1.4.54
IUBMB Enzyme Nomenclature3.1.4.54
IntEnz3.1.4.54
MEDLINEFind literature relating to 3.1.4.54
MetaCyc3.1.4.54
Rhea expert-curated reactions3.1.4.54
UniProtKB/Swiss-Prot
Q02883, FMP30_YEASTQ965X7, NAPE1_CAEELQ965X9, NAPE2_CAEEL
Q58CN9, NAPEP_BOVINQ6IQ20, NAPEP_HUMANQ8BH82, NAPEP_MOUSE
Q5RCU3, NAPEP_PONABQ769K2, NAPEP_RAT

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