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ENZYME entry: EC 3.1.4.54

Accepted Name
N-acetylphosphatidylethanolamine-hydrolyzing phospholipase D.
Alternative Name(s)
Anandamide-generating phospholipase D.
N-acyl phosphatidylethanolamine phospholipase D.
Reaction catalysed
An N-acylphosphatidylethanolamine + H(2)O <=> an N-acylethanolamine + a 1,2-diacylglycerol 3-phosphate
Cofactor(s)
Zn(2+).
Comment(s)
  • This enzyme is involved in the biosynthesis of anandamide.
  • It does not hydrolyze phosphatidylcholine and phosphatidylethanolamine.
  • No transphosphatidation.
Cross-references
BRENDA3.1.4.54
EC2PDB3.1.4.54
ExplorEnz3.1.4.54
PRIAM enzyme-specific profiles3.1.4.54
KEGG Ligand Database for Enzyme Nomenclature3.1.4.54
IUBMB Enzyme Nomenclature3.1.4.54
IntEnz3.1.4.54
MEDLINEFind literature relating to 3.1.4.54
MetaCyc3.1.4.54
Rhea expert-curated reactions3.1.4.54
UniProtKB/Swiss-Prot
Q02883, FMP30_YEAST;  Q965X7, NAPE1_CAEEL;  Q965X9, NAPE2_CAEEL;  
Q58CN9, NAPEP_BOVIN;  Q6IQ20, NAPEP_HUMAN;  Q8BH82, NAPEP_MOUSE;  
Q5RCU3, NAPEP_PONAB;  Q769K2, NAPEP_RAT;  

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