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ENZYME entry: EC 3.1.4.58

Accepted Name
RNA 2',3'-cyclic 3'-phosphodiesterase.
Reaction catalysed
a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + H2O <=> a 3'-end 2'-phospho-ribonucleotide-RNA + H(+)
Comment(s)
  • The enzyme hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.
  • In vitro the enzyme can also ligate tRNA molecules with 2',3'-cyclic phosphate to tRNA with 5'-hydroxyl termini, forming a 2'-5' phosphodiester linkage.
  • However, the ligase activity is unlikely to be relevant in vivo.
Cross-references
BRENDA3.1.4.58
EC2PDB3.1.4.58
ExplorEnz3.1.4.58
PRIAM enzyme-specific profiles3.1.4.58
KEGG Ligand Database for Enzyme Nomenclature3.1.4.58
IUBMB Enzyme Nomenclature3.1.4.58
IntEnz3.1.4.58
MEDLINEFind literature relating to 3.1.4.58
MetaCyc3.1.4.58
Rhea expert-curated reactions3.1.4.58
UniProtKB/Swiss-Prot
Q9YB03, THPR_AERPE;  O66967, THPR_AQUAE;  O28125, THPR_ARCFU;  
O34570, THPR_BACSU;  P37025, THPR_ECOLI;  Q45633, THPR_GEOSE;  
Q58963, THPR_METJA;  O26683, THPR_METTH;  Q8U4Q3, THPR_PYRFU;  
O57823, THPR_PYRHO;  Q9X2H4, THPR_THEMA;  Q5SHB1, THPR_THET8;  

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