ID 3.1.4.60 DE PApA phosphodiesterase. AN PApA hydrolase. CA 5'-O-phosphonoadenylyl-(3'->5')-adenosine + H(2)O = 2 AMP. CC -!- The enzyme, characterized from the Gram-positive bacterium CC Staphylococcus aureus, is a cytoplasmic protein that contains a CC DHH/DHHA1 domain. CC -!- It can act on cyclic di-3',5'-adenylate with a much lower activity CC (cf. EC 3.1.4.59). CC -!- Activity requires Mn(2+) and is inhibited by ppGpp. //