ID 3.1.4.61 DE cyclic 2,3-diphosphoglycerate hydrolase. CA cyclic (2R)-2,3-bisphosphoglycerate + H2O = (2R)-2,3-bisphosphoglycerate CA + 2 H(+). CC -!- The enzyme degrades cyclic 2,3-bisphosphoglycerate, CC a thermoprotectant that is produced by certain archaeal genera. CC -!- Two different enzymes that catalyze this activity, one soluble and CC one membrane-bound, have been characterized from the archaeon CC Methanothermobacter thermautotrophicus. //