ID 3.1.4.62 DE phosphatidylethanolamine phospholipase C. AN phosphatidylethanolamine-specific phospholipase C. CA a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H2O = phosphoethanolamine CA + a 1,2-diacyl-sn-glycerol + H(+). CC -!- This activity, which is similar to that of EC 3.1.4.3, has been CC characterized from mammalian cells. CC -!- Multiple enzymes have been shown to catalyze this activity, including CC human sphingomyelin synthase-related protein (SMSr, gene name; SAMD8) CC and sphingomyelin synthase 1 (SMS1, gene name; SGMS1) (cf. CC EC 2.7.8.27). CC -!- Minor activity was also observed by sphingomyelin synthase 2 (SMS2, CC gene name; SGMS2). DR Q96LT4, SAMD8_HUMAN; Q9DA37, SAMD8_MOUSE; //