ID   3.1.6.1
DE   arylsulfatase (type I).
AN   aryl-sulfate sulphohydrolase.
AN   sulfatase.
CA   an aryl sulfate + H2O = a phenol + H(+) + sulfate.
CC   -!- Sulfatase enzymes are classified as type I, in which the key
CC       catalytic residue is 3-oxo-L-alanine, type II, which are non-heme
CC       iron-dependent dioxygenases, or type III, whose catalytic domain
CC       adopts a metallo-beta-lactamase fold and binds two zinc ions as
CC       cofactors.
CC   -!- Arylsulfatases are type I enzymes, found in both prokaryotes and
CC       eukaryotes, with rather similar specificities.
CC   -!- The key catalytic residue 3-oxo-L-alanine initiates the reaction
CC       through a nucleophilic attack on the sulfur atom in the substrate.
CC   -!- This residue is generated by post-translational modification of a
CC       conserved cysteine or serine residue by EC 1.8.3.7, EC 1.1.98.7,
CC       or EC 1.8.98.7.
DR   P54793, ARSF_HUMAN ;  Q32KH9, ARSG_CANLF ;  Q96EG1, ARSG_HUMAN ;
DR   Q3TYD4, ARSG_MOUSE ;  Q32KJ9, ARSG_RAT   ;  Q148F3, ARSK_BOVIN ;
DR   Q32KH0, ARSK_CANLF ;  Q5ZK90, ARSK_CHICK ;  Q08CJ7, ARSK_DANRE ;
DR   Q6UWY0, ARSK_HUMAN ;  Q9D2L1, ARSK_MOUSE ;  Q32KJ2, ARSK_RAT   ;
DR   Q0IHJ2, ARSK_XENLA ;  P51690, ARSL_HUMAN ;  Q60HH5, ARSL_MACFA ;
DR   P14217, ARS_CHLRE  ;  P14000, ARS_HEMPU  ;  P51691, ARS_PSEAE  ;
DR   P28607, ARS_PSEVC  ;  P50473, ARS_STRPU  ;  Q10723, ARS_VOLCA  ;
DR   P20713, ATSA_KLEAE ;  Q9X759, ATSA_KLEPN ;  Q8IWU6, SULF1_HUMAN;
DR   Q8K007, SULF1_MOUSE;  Q8VI60, SULF1_RAT  ;  Q8IWU5, SULF2_HUMAN;
DR   Q8CFG0, SULF2_MOUSE;  Q0TUK6, SULF_CLOP1 ;  Q8XNV1, SULF_CLOPE ;
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