ID   3.1.6.21
DE   linear primary-alkylsulfatase.
AN   type III linear primary-alkylsulfatase.
CA   a primary linear alkyl sulfate ester + H2O = a primary alcohol + H(+) +
CA   sulfate.
CC   -!- Sulfatase enzymes are classified as type I, in which the key
CC       catalytic residue is 3-oxo-L-alanine, type II, which are non-heme
CC       iron-dependent dioxygenases, or type III, whose catalytic domain
CC       adopts a metallo-beta-lactamase fold and binds two zinc ions as
CC       cofactors.
CC   -!- This enzyme belongs to the type III sulfatase family.
CC   -!- The enzyme is active against linear primary-alkyl sulfate esters,
CC       such as dodecyl sulfate, decyl sulfate, octyl sulfate, and hexyl
CC       sulfate.
CC   -!- The enzyme from Pseudomonas aeruginosa is secreted out of the cell.
CC   -!- The catalytic mechanism begins with activation of a water molecule by
CC       the binuclear Zn(2+) cluster, resulting in a nucleophilic attack on
CC       the carbon atom. cf. EC 3.1.6.19 and EC 3.1.6.22.
DR   P32717, LPAKS_ECOLI;  Q9I5I9, LPAKS_PSEAE;  Q52556, LPAKS_PSES9;
DR   F2WP51, LPAKS_PSESP;
//