ID 3.13.1.9 DE S-inosyl-L-homocysteine hydrolase. CA H2O + S-inosyl-L-homocysteine = inosine + L-homocysteine. CC -!- The enzyme, characterized from the methanogenic archaeon CC Methanocaldococcus jannaschii, binds an NAD(+) cofactor. CC -!- It participates in an alternative pathway for the regeneration of CC S-adenosyl-L-methionine from S-adenosyl-L-homocysteine that involves CC the deamination of the latter to S-inosyl-L-homocysteine. DR Q8TRA5, SIHH_METAC ; Q58783, SIHH_METJA ; P58855, SIHH_METKA ; DR Q8PUQ4, SIHH_METMA ; Q6LYR8, SIHH_METMP ; O27673, SIHH_METTH ; //