ID   3.13.2.4
DE   lanthipeptide synthase.
CA   (1) a [protein]-L-serine + a [protein]-L-cysteine = a [protein] with
CA   lanthionine cross-link + H2O (overall reaction).
CA   (2) a [protein]-L-threonine + a [protein]-L-cysteine = a [protein] with
CA   3-methyllanthionine cross-link + H2O (overall reaction).
CC   -!- The lanthipeptides are a family of ribosomally synthesized and post-
CC       translationally modified peptides (RiPPs) that is characterized by
CC       the presence of multiple lanthionine (Lan) and 3-methyllanthionine
CC       (MeLan) crosslinks, which are formed by lanthipeptide synthases.
CC   -!- These enzymes catalyze dehydration of Ser/Thr residues, followed by
CC       intramolecular addition of the thiol group of a Cys residue to the
CC       dehydro amino acids, which results in the formation of the thioether
CC       crosslinks of (methyl)lanthionine.
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