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ENZYME

ENZYME entry: EC 3.2.1.106

PURL: https://purl.expasy.org/enzyme/EC/3.2.1.106
Accepted Name
mannosyl-oligosaccharide glucosidase
Alternative Name(s)
Glc3Man9NAc2 oligosaccharide glucosidase
processing A-glucosidase I
Reaction catalysed
N(4)-(alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] + H2O = N(4)-(alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] + beta-D-glucose
Comment(s)
  • This enzyme catalyzes the first step in the processing of the N-glycan tetradecasaccharide precursor Glc3Man9GlcNAc2, which takes place in the endoplasmic reticulum, by removing the distal alpha-1,2- linked glucose residue.
  • This and subsequent processing steps are required before complex N-glycans can be synthesized.
Cross-references
BRENDA3.2.1.106
EC2PDB3.2.1.106
ExplorEnz3.2.1.106
KEGG Ligand Database for Enzyme Nomenclature3.2.1.106
IUBMB Enzyme Nomenclature3.2.1.106
MEDLINEFind literature relating to 3.2.1.106
MetaCyc3.2.1.106
Rhea expert-curated reactions3.2.1.106
UniProtKB/Swiss-Prot
P53008, CWH41_YEASTF4HTM3, GCS1_ARATHO14255, GCS1_SCHPO
Q19426, MOGS1_CAEELQ13724, MOGS_HUMANQ80UM7, MOGS_MOUSE
O88941, MOGS_RAT

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