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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC

Accepted Name
Mannosyl-oligosaccharide glucosidase.
Alternative Name(s)
Glc3Man9NAc(2) oligosaccharide glucosidase.
Processing A-glucosidase I.
Reaction catalysed
Glc(3)Man(9)GlcNAc(2)-[protein] + H(2)O <=> Glc(2)Man(9)GlcNAc(2)-[protein] + beta-D-glucopyranose
  • This enzyme catalyzes the first step in the processing of the N-glycan tetradecasaccharide precursor Glc(3)Man(9)GlcNAc(2), which takes place in the endoplasmic reticulum, by removing the distal alpha-1,2-linked glucose residue.
  • This and subsequent processing steps are required before complex N-glycans can be synthesized.
PRIAM enzyme-specific profiles3.2.1.106
KEGG Ligand Database for Enzyme Nomenclature3.2.1.106
IUBMB Enzyme Nomenclature3.2.1.106
MEDLINEFind literature relating to
P53008, CWH41_YEAST;  F4HTM3, GCS1_ARATH;  O14255, GCS1_SCHPO;  
Q19426, MOGS1_CAEEL;  Q13724, MOGS_HUMAN;  Q80UM7, MOGS_MOUSE;  
O88941, MOGS_RAT;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.2.1.-
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