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ENZYME entry: EC 3.2.1.106

Accepted Name
Mannosyl-oligosaccharide glucosidase.
Alternative Name(s)
Glc3Man9NAc(2) oligosaccharide glucosidase.
Processing A-glucosidase I.
Reaction catalysed
Glc(3)Man(9)GlcNAc(2)-[protein] + H(2)O <=> Glc(2)Man(9)GlcNAc(2)-[protein] + beta-D-glucopyranose
Comment(s)
  • This enzyme catalyzes the first step in the processing of the N-glycan tetradecasaccharide precursor Glc(3)Man(9)GlcNAc(2), which takes place in the endoplasmic reticulum, by removing the distal alpha-1,2-linked glucose residue.
  • This and subsequent processing steps are required before complex N-glycans can be synthesized.
Cross-references
BRENDA3.2.1.106
EC2PDB3.2.1.106
ExplorEnz3.2.1.106
PRIAM enzyme-specific profiles3.2.1.106
KEGG Ligand Database for Enzyme Nomenclature3.2.1.106
IUBMB Enzyme Nomenclature3.2.1.106
IntEnz3.2.1.106
MEDLINEFind literature relating to 3.2.1.106
MetaCyc3.2.1.106
Rhea expert-curated reactions3.2.1.106
UniProtKB/Swiss-Prot
P53008, CWH41_YEAST;  F4HTM3, GCS1_ARATH;  O14255, GCS1_SCHPO;  
Q19426, MOGS1_CAEEL;  Q13724, MOGS_HUMAN;  Q80UM7, MOGS_MOUSE;  
O88941, MOGS_RAT;  

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