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ENZYME entry: EC 3.2.1.106

Accepted Name
mannosyl-oligosaccharide glucosidase.
Alternative Name(s)
Glc3Man9NAc2 oligosaccharide glucosidase.
processing A-glucosidase I.
Reaction catalysed
H2O + N(4)-(alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] <=> beta-D-glucose + N(4)-(alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein]
Comment(s)
  • This enzyme catalyzes the first step in the processing of the N-glycan tetradecasaccharide precursor Glc3Man9GlcNAc2, which takes place in the endoplasmic reticulum, by removing the distal alpha-1,2- linked glucose residue.
  • This and subsequent processing steps are required before complex N-glycans can be synthesized.
Cross-references
BRENDA3.2.1.106
EC2PDB3.2.1.106
ExplorEnz3.2.1.106
PRIAM enzyme-specific profiles3.2.1.106
KEGG Ligand Database for Enzyme Nomenclature3.2.1.106
IUBMB Enzyme Nomenclature3.2.1.106
IntEnz3.2.1.106
MEDLINEFind literature relating to 3.2.1.106
MetaCyc3.2.1.106
Rhea expert-curated reactions3.2.1.106
UniProtKB/Swiss-Prot
P53008, CWH41_YEAST;  F4HTM3, GCS1_ARATH;  O14255, GCS1_SCHPO;  
Q19426, MOGS1_CAEEL;  Q13724, MOGS_HUMAN;  Q80UM7, MOGS_MOUSE;  
O88941, MOGS_RAT;  

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