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ENZYME entry: EC 3.2.1.107

Accepted Name
protein-glucosylgalactosylhydroxylysine glucosidase.
Reaction catalysed
(5R)-5-O-[alpha-D-glucosyl-(1->2)-beta-D-galactosyl]-5-hydroxy-L-lysyl-[collagen] + H2O <=> (5R)-5-O-(beta-D-galactosyl)-5-hydroxy-L-lysyl-[collagen] + D-glucose
Comment(s)
  • The enzyme specifically hydrolyzes glucose from alpha-D-glucosyl- (1->2)-beta-D-galactosyl disaccharide units that are linked to hydroxylysine residues of collagen and collagen-like proteins.
  • Acetylation of the epsilon-amino group of the glycosylated hydroxylysine abolishes activity.
Cross-references
BRENDA3.2.1.107
EC2PDB3.2.1.107
ExplorEnz3.2.1.107
PRIAM enzyme-specific profiles3.2.1.107
KEGG Ligand Database for Enzyme Nomenclature3.2.1.107
IUBMB Enzyme Nomenclature3.2.1.107
IntEnz3.2.1.107
MEDLINEFind literature relating to 3.2.1.107
MetaCyc3.2.1.107
Rhea expert-curated reactions3.2.1.107
UniProtKB/Swiss-Prot
F1NZI4, PGGHG_CHICK;  A0JMP0, PGGHG_DANRE;  Q54KX5, PGGHG_DICDI;  
Q32M88, PGGHG_HUMAN;  Q8BP56, PGGHG_MOUSE;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.2.1.-
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