ID 3.2.1.114 DE mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase. AN ManII. AN mannosidase II. CA 2 H2O + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man- CA (1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D- CA GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] = 2 alpha-D- CA mannopyranose + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D- CA Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L- CA asparaginyl-[protein]. CC -!- The enzyme, found in plants and animals, participates in the CC processing of N-glycans in the Golgi apparatus. CC -!- It removes two mannosyl residues, one linked by alpha1,3 linkage, CC and the other linked by alpha1,6 linkage, both of which are removed CC by the same catalytic site. CC -!- The enzyme is sensitive to swainsonine. DR Q9LFR0, GMAN2_ARATH; Q16706, MA2A1_HUMAN; P27046, MA2A1_MOUSE; DR P28494, MA2A1_RAT ; P49641, MA2A2_HUMAN; Q8BRK9, MA2A2_MOUSE; DR Q24451, MAN2_DROME ; O18497, MAN2_SPOFR ; //