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ENZYME entry: EC 3.2.1.166

Accepted Name
Heparanase.
Alternative Name(s)
Hpa1 heparanase.
HPSE.
Reaction catalysed
Endohydrolysis of (1->4)-beta-D-glycosidic bonds of heparan sulfate chains in heparan sulfate proteoglycan
Comment(s)
  • Heparanase cleaves the linkage between a glucuronic acid unit and an N-sulfo glucosamine unit carrying either a 3-O-sulfo or a 6-O-sulfo group.
  • Heparanase-1 cuts macromolecular heparin into fragments of 5000-20000 Da.
  • The enzyme cleaves the heparan sulfate glycosaminoglycans from proteoglycan core proteins and degrades them to small oligosaccharides.
  • Inside cells, the enzyme is important for the normal catabolism of heparan sulfate proteoglycans, generating glycosaminoglycan fragments that are then transported to lysosomes and completely degraded.
  • When secreted, heparanase degrades basement membrane heparan sulfate glycosaminoglycans at sites of injury or inflammation, allowing extravasion of immune cells into nonvascular spaces and releasing factors that regulate cell proliferation and angiogenesis.
Cross-references
BRENDA3.2.1.166
EC2PDB3.2.1.166
ExplorEnz3.2.1.166
PRIAM enzyme-specific profiles3.2.1.166
KEGG Ligand Database for Enzyme Nomenclature3.2.1.166
IUBMB Enzyme Nomenclature3.2.1.166
IntEnz3.2.1.166
MEDLINEFind literature relating to 3.2.1.166
MetaCyc3.2.1.166
Rhea expert-curated reactions3.2.1.166
UniProtKB/Swiss-Prot
Q9MYY0, HPSE_BOVIN;  Q90YK5, HPSE_CHICK;  Q9Y251, HPSE_HUMAN;  
Q6YGZ1, HPSE_MOUSE;  Q71RP1, HPSE_RAT;  

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