ID   3.2.1.169
DE   protein O-GlcNAcase.
AN   glycoside hydrolase O-GlcNAcase.
AN   OGA.
AN   O-GlcNAcase.
AN   O-GlcNAc hydrolase.
CA   (1) 3-O-(N-acetyl-beta-D-glucosaminyl)-L-seryl-[protein] + H2O = L-seryl-
CA   [protein] + N-acetyl-D-glucosamine.
CA   (2) 3-O-(N-acetyl-beta-D-glucosaminyl)-L-threonyl-[protein] + H2O =
CA   L-threonyl-[protein] + N-acetyl-D-glucosamine.
CC   -!- Within higher eukaryotes post-translational modification of protein
CC       serines/threonines with N-acetylglucosamine (O-GlcNAc) is dynamic,
CC       inducible and abundant, regulating many cellular processes by
CC       interfering with protein phosphorylation.
CC   -!- EC 2.4.1.155 transfers GlcNAc onto substrate proteins and
CC       EC 3.2.1.169 cleaves GlcNAc from the modified proteins.
DR   Q89ZI2, OGA_BACTN  ;  Q0TR53, OGA_CLOP1  ;  Q8XL08, OGA_CLOPE  ;
DR   O60502, OGA_HUMAN  ;  Q9EQQ9, OGA_MOUSE  ;  Q2CEE3, OGA_OCEGH  ;
DR   Q8VIJ5, OGA_RAT    ;
//