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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC 3.2.1.178

Accepted Name
Beta-porphyranase.
Alternative Name(s)
Endo-beta-porphyranase.
Porphyranase.
Reaction catalysed
Hydrolysis of beta-D-galactopyranose-(1->4)-alpha-L-galactopyranose-6-sulfate linkages in porphyran
Comment(s)
  • The backbone of porphyran consists largely (approximately 70%) of (1->3)-linked beta-D-galactopyranose followed by (1->4)-linked alpha- L-galactopyranose-6-sulfate (the other 30% are mostly agarobiose repeating units of (1->3)-linked beta-D-galactopyranose followed by (1->4)-linked 3,6-anhydro-alpha-L-galactopyranose).
  • This enzyme cleaves the (1->4) linkages between beta-D- galactopyranose and alpha-L-galactopyranose-6-sulfate, forming mostly the disaccharide alpha-L-galactopyranose-6-sulfate-(1->3)-beta-D- galactose, although some longer oligosaccharides of even number of residues are also observed.
  • Since the enzyme is inactive on the non-sulfated agarose portion of the porphyran backbone, some agarose fragments are also included in the products.
  • Methylation of the D-galactose prevents its binding at position -1.
Cross-references
BRENDA3.2.1.178
EC2PDB3.2.1.178
ExplorEnz3.2.1.178
PRIAM enzyme-specific profiles3.2.1.178
KEGG Ligand Database for Enzyme Nomenclature3.2.1.178
IUBMB Enzyme Nomenclature3.2.1.178
IntEnz3.2.1.178
MEDLINEFind literature relating to 3.2.1.178
MetaCyc3.2.1.178
UniProtKB/Swiss-Prot
B5CY96, PORA_BACPM;  D7GXG0, PORA_ZOBGA;  B5CY92, PORB_BACPM;  
D7GXF9, PORB_ZOBGA;  D7GXG1, PORC_ZOBGA;  D7GXG2, PORD_ZOBGA;  
D7GXG3, PORE_ZOBGA;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.2.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.2.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.-.-.-