ENZYME

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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC 3.2.1.179

Accepted Name

Gellan tetrasaccharide unsaturated glucuronosyl hydrolase.

Alternative Name(s)

Gellan tetrasaccharide unsaturated glucuronyl hydrolase.

Unsaturated glucuronyl hydrolase.

Reaction catalysed

Beta-D-4-deoxy-Delta(4)-GlcAp-(1->4)-beta-D-Glcp-(1->4)-alpha-L-Rhap-(1->3)-D-Glcp + H(2)O <=> 5-dehydro-4-deoxy-D-glucuronate + beta-D-Glcp-(1->4)-alpha-L-Rhap-(1->3)-D-Glcp

Comment(s)

The enzyme releases 4-deoxy-4(5)-unsaturated D-glucuronic acid from oligosaccharides produced by polysaccharide lyases, e.g. the tetrasaccharide beta-D-4-deoxy-Delta(4)-GlcAp-(1->4)-beta-D-Glcp- (1->4)-alpha-L-Rhap-(1->3)-D-Glcp produced by EC 4.2.2.25.
The enzyme can also hydrolyze unsaturated chondroitin and hyaluronate disaccharides (beta-D-4-deoxy-Delta(4)-GlcAp-(1->3)-beta-D-GalNAc, beta-D-4-deoxy-Delta(4)-GlcAp-(1->3)-beta-D-GalNAc6S, beta-D-4-deoxy- Delta(4)-GlcAp2S-(1->3)-beta-D-GalNAc, beta-D-4-deoxy-Delta(4)-GlcAp- (1->3)-beta-D-GlcNAc), preferring the unsulfated disaccharides to the sulfated disaccharides.

Cross-references

BRENDA

3.2.1.179

EC2PDB

3.2.1.179

ExplorEnz

3.2.1.179

PRIAM enzyme-specific profiles

3.2.1.179

KEGG Ligand Database for Enzyme Nomenclature

3.2.1.179

IUBMB Enzyme Nomenclature