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ENZYME

ENZYME entry: EC 3.2.1.179

PURL: https://purl.expasy.org/enzyme/EC/3.2.1.179
Accepted Name
gellan tetrasaccharide unsaturated glucuronosyl hydrolase
Alternative Name(s)
gellan tetrasaccharide unsaturated glucuronyl hydrolase
unsaturated glucuronyl hydrolase
Reaction catalysed
beta-D-Delta(4)-GlcA-(1->4)-beta-D-Glc-(1->4)-alpha-L-Rha-(1->3)-D-Glc + H2O = beta-D-Glc-(1->4)-alpha-L-Rha-(1->3)-D-Glc + 5-dehydro-4-deoxy-D-glucuronate
Comment(s)
  • The enzyme releases 4-deoxy-4(5)-unsaturated D-glucuronic acid from oligosaccharides produced by polysaccharide lyases, e.g. the tetrasaccharide beta-D-4-deoxy-Delta(4)-GlcAp-(1->4)-beta-D-Glcp- (1->4)-alpha-L-Rhap-(1->3)-D-Glcp produced by EC 4.2.2.25.
  • The enzyme can also hydrolyze unsaturated chondroitin and hyaluronate disaccharides (beta-D-4-deoxy-Delta(4)-GlcAp-(1->3)-beta-D-GalNAc, beta-D-4-deoxy-Delta(4)-GlcAp-(1->3)-beta-D-GalNAc6S, beta-D-4-deoxy- Delta(4)-GlcAp2S-(1->3)-beta-D-GalNAc, beta-D-4-deoxy-Delta(4)-GlcAp- (1->3)-beta-D-GlcNAc), preferring the unsulfated disaccharides to the sulfated disaccharides.
Cross-references
BRENDA3.2.1.179
EC2PDB3.2.1.179
ExplorEnz3.2.1.179
KEGG Ligand Database for Enzyme Nomenclature3.2.1.179
IUBMB Enzyme Nomenclature3.2.1.179
MEDLINEFind literature relating to 3.2.1.179
MetaCyc3.2.1.179
Rhea expert-curated reactions3.2.1.179
UniProtKB/Swiss-Prot
Q9RC92, UGL_BACGL

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