ENZYME entry: EC 3.2.1.18

PURL: https://purl.expasy.org/enzyme/EC/3.2.1.18

Accepted Name

exo-alpha-sialidase

Alternative Name(s)

alpha-neuraminidase

N-acylneuraminate glycohydrolase

neuraminidase

sialidase

Reaction catalysed

Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates

Comment(s)

The enzyme does not act on 4-O-acetylated sialic acids.
An endo-alpha-sialidase activity is listed as EC 3.2.1.129.
See also EC 4.2.2.15.

Cross-references

Rhea expert-curated reactions

3.2.1.18

ExplorEnz

3.2.1.18

IUBMB Enzyme Nomenclature

3.2.1.18

UniProtKB/Swiss-Prot

P18269, 8511_TRYCR	P18270, 8512_TRYCR	P18271, 8513_TRYCR
P19762, HN_MUMP1	Q8QV65, HN_MUMPJ	P11235, HN_MUMPM
P10866, HN_MUMPR	Q9WAF5, HN_MUMPV	Q5SC51, HN_MUMPZ
P12554, HN_NDVA	P32884, HN_NDVB	Q91UL0, HN_NDVB1
P35740, HN_NDVC	P12555, HN_NDVD	P35741, HN_NDVH3
P12559, HN_NDVH4	P12556, HN_NDVI	P35742, HN_NDVJ
Q9Q2W5, HN_NDVK	P35743, HN_NDVL	P12557, HN_NDVM
P13850, HN_NDVQ	P12553, HN_NDVTG	P12558, HN_NDVU
P16071, HN_PI1HW	P25465, HN_PI2H	P25466, HN_PI2HT
P06167, HN_PI3B	P08492, HN_PI3H4	P12561, HN_PI3HA
P12562, HN_PI3HT	P12563, HN_PI3HU	P12564, HN_PI3HV
P12565, HN_PI3HW	P12566, HN_PI3HX	P21526, HN_PI4HA
P04850, HN_PIV5	P28883, HN_PIV5C	P28884, HN_PIV5D
P28885, HN_PIV5L	Q783Y1, HN_SENDA	P19758, HN_SENDF
P03425, HN_SENDH	Q88261, HN_SENDO	P04853, HN_SENDZ
P25180, HN_SV41	P62575, NANA_STREE	P62576, NANA_STRR6
Q54727, NANB_STRPN	P31206, NANH_BACFR	P10481, NANH_CLOPF
P29767, NANH_CLOSE	Q02834, NANH_MICVI	P15698, NANH_PARSO
P29768, NANH_SALTY	A5F7A4, NANH_VIBC3	P0C6E9, NANH_VIBCH
A6BMK7, NEUR1_BOVIN	Q99519, NEUR1_HUMAN	O35657, NEUR1_MOUSE
A5PF10, NEUR1_PIG	Q5RAF4, NEUR1_PONAB	Q99PW3, NEUR1_RAT
Q64393, NEUR2_CRIGR	Q9Y3R4, NEUR2_HUMAN	Q9JMH3, NEUR2_MOUSE
Q64627, NEUR2_RAT	O97859, NEUR3_BOVIN	Q9UQ49, NEUR3_HUMAN
Q9JMH7, NEUR3_MOUSE	Q99PW5, NEUR3_RAT	Q8WWR8, NEUR4_HUMAN
Q8BZL1, NEUR4_MOUSE	P18881, NRAM_I000F	Q8QPK2, NRAM_I00A0
Q289M4, NRAM_I00A1	Q809V0, NRAM_I01A0	Q809V4, NRAM_I01A1
Q809V2, NRAM_I01A2	Q809U7, NRAM_I01A3	Q6DPK2, NRAM_I02A1
Q6DPK1, NRAM_I02A2	Q6DPK0, NRAM_I02A3	Q6DPJ9, NRAM_I02A4
Q6J8D5, NRAM_I02A5	Q6DPJ8, NRAM_I02A6	Q6DPI6, NRAM_I02A7
Q6J8E4, NRAM_I03A0	Q6DPH9, NRAM_I03A1	Q6DPL2, NRAM_I04A1
Q2LFV4, NRAM_I05A1	B4URD9, NRAM_I06A0	A8C8J7, NRAM_I07A0
Q9IGQ6, NRAM_I18A0	P03470, NRAM_I33A0	Q64968, NRAM_I34A0
P03468, NRAM_I34A1	A4GCM2, NRAM_I35A3	A4GCI9, NRAM_I36A0
Q0HD57, NRAM_I40A0	A4GCL1, NRAM_I43A0	A4U6V5, NRAM_I45A0
Q8JSD9, NRAM_I47A0	P03480, NRAM_I49A1	A4U7A9, NRAM_I51A0
P31349, NRAM_I54A0	A4K146, NRAM_I54A2	A3KF10, NRAM_I56A1
Q6XV27, NRAM_I56A2	P88838, NRAM_I56A3	Q1K9Q1, NRAM_I57A0
Q67212, NRAM_I57A1	Q67214, NRAM_I57A2	P03484, NRAM_I57A4
Q6XUE4, NRAM_I57A5	Q710U6, NRAM_I59A0	Q6XUD6, NRAM_I60A0
Q6XV52, NRAM_I61A0	B3EUQ9, NRAM_I61A1	Q595Z2, NRAM_I63A1
Q07579, NRAM_I63A2	Q07599, NRAM_I63A3	Q07584, NRAM_I65A0
Q0A456, NRAM_I66A1	P06820, NRAM_I67A0	A8C8W6, NRAM_I67A2
Q75VQ4, NRAM_I68A0	P03477, NRAM_I68A3	Q91MA2, NRAM_I68A4
Q6XUA7, NRAM_I68A5	P03473, NRAM_I68A6	Q6XTN2, NRAM_I69A0
Q07581, NRAM_I69A2	Q6XTM7, NRAM_I70A0	P03471, NRAM_I71A1
P03476, NRAM_I71A2	Q07576, NRAM_I72A0	Q07571, NRAM_I72A1
P0DOF6, NRAM_I72A2	P03475, NRAM_I72A3	Q2ICQ7, NRAM_I72A4
P03478, NRAM_I72A5	P0DOF9, NRAM_I72A8	P06819, NRAM_I73A0
Q1PUD6, NRAM_I73A5	P08327, NRAM_I74A1	Q07573, NRAM_I74A2
Q30NP8, NRAM_I75A0	P03482, NRAM_I75A3	P03472, NRAM_I75A5
P03479, NRAM_I76A1	Q2RFA3, NRAM_I76A6	Q76WJ1, NRAM_I76A7
Q09104, NRAM_I76A9	Q09105, NRAM_I76AB	Q9IGQ0, NRAM_I76AI
Q6XV26, NRAM_I76AK	Q9EA42, NRAM_I77A4	A4GBY0, NRAM_I77AA
P03469, NRAM_I77AB	Q6XV23, NRAM_I77AF	Q6XV28, NRAM_I77AG
Q75VQ0, NRAM_I77AH	P03481, NRAM_I78A0	Q2VNF0, NRAM_I78A7
Q2VND0, NRAM_I78A8	Q09106, NRAM_I78AB	Q07585, NRAM_I78AC
P06818, NRAM_I79A0	P31348, NRAM_I79A4	Q07580, NRAM_I79A6
Q6XV43, NRAM_I79A7	Q2VC95, NRAM_I80A2	Q2RCH3, NRAM_I80A4
Q07572, NRAM_I80A6	Q20NP0, NRAM_I80A8	A4GCK0, NRAM_I80AA
Q20NV8, NRAM_I80AD	P08326, NRAM_I81A2	P26143, NRAM_I82A2
Q67344, NRAM_I82A7	P11485, NRAM_I83A1	Q0A2G2, NRAM_I83A4
Q0A2I4, NRAM_I83A5	P09573, NRAM_I83A6	P09574, NRAM_I83A7
Q38SQ5, NRAM_I83A8	Q07574, NRAM_I84A0	P05803, NRAM_I84A1
Q6XV24, NRAM_I84A4	Q0A2R1, NRAM_I85A3	Q6TXB9, NRAM_I85A5
P31510, NRAM_I85A8	Q07582, NRAM_I86A3	Q07570, NRAM_I88A1
Q07577, NRAM_I88A4	Q07578, NRAM_I89A7	Q07583, NRAM_I90A1
Q07575, NRAM_I91A0	O91744, NRAM_I93A0	Q9Q0U7, NRAM_I96A0
O91745, NRAM_I96A1	A3DRP3, NRAM_I96A2	Q07FI2, NRAM_I96A3
Q9WAA1, NRAM_I97A0	Q9W7Y7, NRAM_I97A1	P27907, NRAM_INBBE
P16191, NRAM_INBHK	P03474, NRAM_INBLE	P67923, NRAM_INBLN
P16195, NRAM_INBMD	P67907, NRAM_INBME	P16199, NRAM_INBMF
P16201, NRAM_INBOR	P16203, NRAM_INBSI	P16205, NRAM_INBUS
P16207, NRAM_INBVI	Q90021, NRAM_INBYB	D4B4P1, SIA_ARTBC
Q4WQS0, SIA_ASPFU	P23253, TCNA_TRYCR

BRENDA

3.2.1.18

MetaCyc

3.2.1.18

KEGG Ligand Database for Enzyme Nomenclature

3.2.1.18

EC2PDB

3.2.1.18

MEDLINE

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