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ENZYME

ENZYME entry: EC 3.2.1.18

Accepted Name
exo-alpha-sialidase
Alternative Name(s)
alpha-neuraminidase
N-acylneuraminate glycohydrolase
neuraminidase
sialidase
Reaction catalysed
Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates
Comment(s)
  • The enzyme does not act on 4-O-acetylated sialic acids.
  • An endo-alpha-sialidase activity is listed as EC 3.2.1.129.
  • See also EC 4.2.2.15.
Cross-references
BRENDA3.2.1.18
EC2PDB3.2.1.18
ExplorEnz3.2.1.18
PRIAM enzyme-specific profiles3.2.1.18
KEGG Ligand Database for Enzyme Nomenclature3.2.1.18
IUBMB Enzyme Nomenclature3.2.1.18
IntEnz3.2.1.18
MEDLINEFind literature relating to 3.2.1.18
MetaCyc3.2.1.18
Rhea expert-curated reactions3.2.1.18
UniProtKB/Swiss-Prot
P18269, 8511_TRYCRP18270, 8512_TRYCRP18271, 8513_TRYCR
P19762, HN_MUMP1P11235, HN_MUMPMP10866, HN_MUMPR
P12554, HN_NDVAP32884, HN_NDVBQ91UL0, HN_NDVB1
P35740, HN_NDVCP12555, HN_NDVDP35741, HN_NDVH3
P12559, HN_NDVH4P12556, HN_NDVIP35742, HN_NDVJ
Q9Q2W5, HN_NDVKP35743, HN_NDVLP12557, HN_NDVM
P13850, HN_NDVQP12553, HN_NDVTGP12558, HN_NDVU
P16071, HN_PI1HWP25465, HN_PI2HP25466, HN_PI2HT
P06167, HN_PI3BP08492, HN_PI3H4P12561, HN_PI3HA
P12562, HN_PI3HTP12563, HN_PI3HUP12564, HN_PI3HV
P12565, HN_PI3HWP12566, HN_PI3HXP21526, HN_PI4HA
P04850, HN_PIV5P28883, HN_PIV5CP28884, HN_PIV5D
P28885, HN_PIV5LQ783Y1, HN_SENDAP19758, HN_SENDF
P03425, HN_SENDHQ88261, HN_SENDOP04853, HN_SENDZ
P25180, HN_SV41P62575, NANA_STREEP62576, NANA_STRR6
Q54727, NANB_STRPNP31206, NANH_BACFRP10481, NANH_CLOPF
P29767, NANH_CLOSEQ02834, NANH_MICVIP15698, NANH_PAESO
P29768, NANH_SALTYA5F7A4, NANH_VIBC3P0C6E9, NANH_VIBCH
A6BMK7, NEUR1_BOVINQ99519, NEUR1_HUMANO35657, NEUR1_MOUSE
A5PF10, NEUR1_PIGQ5RAF4, NEUR1_PONABQ99PW3, NEUR1_RAT
Q64393, NEUR2_CRIGRQ9Y3R4, NEUR2_HUMANQ9JMH3, NEUR2_MOUSE
Q64627, NEUR2_RATO97859, NEUR3_BOVINQ9UQ49, NEUR3_HUMAN
Q9JMH7, NEUR3_MOUSEQ99PW5, NEUR3_RATQ8WWR8, NEUR4_HUMAN
Q8BZL1, NEUR4_MOUSEP18881, NRAM_I000FQ8QPK2, NRAM_I00A0
Q289M4, NRAM_I00A1Q809V0, NRAM_I01A0Q809V4, NRAM_I01A1
Q809V2, NRAM_I01A2Q809U7, NRAM_I01A3Q6DPK2, NRAM_I02A1
Q6DPK1, NRAM_I02A2Q6DPK0, NRAM_I02A3Q6DPJ9, NRAM_I02A4
Q6J8D5, NRAM_I02A5Q6DPJ8, NRAM_I02A6Q6DPI6, NRAM_I02A7
Q6J8E4, NRAM_I03A0Q6DPH9, NRAM_I03A1Q2LFV4, NRAM_I05A1
B4URD9, NRAM_I06A0A8C8J7, NRAM_I07A0Q9IGQ6, NRAM_I18A0
P03470, NRAM_I33A0Q64968, NRAM_I34A0P03468, NRAM_I34A1
A4GCM2, NRAM_I35A3A4GCI9, NRAM_I36A0Q0HD57, NRAM_I40A0
A4GCL1, NRAM_I43A0A4U6V5, NRAM_I45A0Q8JSD9, NRAM_I47A0
P03480, NRAM_I49A1A4U7A9, NRAM_I51A0P31349, NRAM_I54A0
A4K146, NRAM_I54A2A3KF10, NRAM_I56A1Q6XV27, NRAM_I56A2
P88838, NRAM_I56A3Q1K9Q1, NRAM_I57A0Q67212, NRAM_I57A1
Q67214, NRAM_I57A2P03484, NRAM_I57A4Q6XUE4, NRAM_I57A5
Q710U6, NRAM_I59A0Q6XUD6, NRAM_I60A0Q6XV52, NRAM_I61A0
B3EUQ9, NRAM_I61A1Q595Z2, NRAM_I63A1Q07579, NRAM_I63A2
Q07599, NRAM_I63A3Q07584, NRAM_I65A0Q0A456, NRAM_I66A1
P06820, NRAM_I67A0A8C8W6, NRAM_I67A2Q75VQ4, NRAM_I68A0
P03477, NRAM_I68A3Q91MA2, NRAM_I68A4Q6XUA7, NRAM_I68A5
P03473, NRAM_I68A6Q6XTN2, NRAM_I69A0Q07581, NRAM_I69A2
Q6XTM7, NRAM_I70A0P03471, NRAM_I71A1P03476, NRAM_I71A2
Q07576, NRAM_I72A0Q07571, NRAM_I72A1P0DOF6, NRAM_I72A2
P03475, NRAM_I72A3Q2ICQ7, NRAM_I72A4P03478, NRAM_I72A5
P0DOF9, NRAM_I72A8P06819, NRAM_I73A0Q1PUD6, NRAM_I73A5
P08327, NRAM_I74A1Q07573, NRAM_I74A2Q30NP8, NRAM_I75A0
P03482, NRAM_I75A3P03472, NRAM_I75A5P03479, NRAM_I76A1
Q2RFA3, NRAM_I76A6Q76WJ1, NRAM_I76A7Q09104, NRAM_I76A9
Q09105, NRAM_I76ABQ9IGQ0, NRAM_I76AIQ6XV26, NRAM_I76AK
Q9EA42, NRAM_I77A4A4GBY0, NRAM_I77AAP03469, NRAM_I77AB
Q6XV23, NRAM_I77AFQ6XV28, NRAM_I77AGQ75VQ0, NRAM_I77AH
P03481, NRAM_I78A0Q2VNF0, NRAM_I78A7Q2VND0, NRAM_I78A8
Q09106, NRAM_I78ABQ07585, NRAM_I78ACP06818, NRAM_I79A0
P31348, NRAM_I79A4Q07580, NRAM_I79A6Q6XV43, NRAM_I79A7
Q2VC95, NRAM_I80A2Q2RCH3, NRAM_I80A4Q07572, NRAM_I80A6
Q20NP0, NRAM_I80A8A4GCK0, NRAM_I80AAQ20NV8, NRAM_I80AD
P08326, NRAM_I81A2P26143, NRAM_I82A2Q67344, NRAM_I82A7
P11485, NRAM_I83A1Q0A2G2, NRAM_I83A4Q0A2I4, NRAM_I83A5
P09573, NRAM_I83A6P09574, NRAM_I83A7Q38SQ5, NRAM_I83A8
Q07574, NRAM_I84A0P05803, NRAM_I84A1Q6XV24, NRAM_I84A4
Q0A2R1, NRAM_I85A3Q6TXB9, NRAM_I85A5P31510, NRAM_I85A8
Q07582, NRAM_I86A3Q07570, NRAM_I88A1Q07577, NRAM_I88A4
Q07578, NRAM_I89A7Q07583, NRAM_I90A1Q07575, NRAM_I91A0
O91744, NRAM_I93A0Q9Q0U7, NRAM_I96A0O91745, NRAM_I96A1
A3DRP3, NRAM_I96A2Q07FI2, NRAM_I96A3Q9WAA1, NRAM_I97A0
Q9W7Y7, NRAM_I97A1P27907, NRAM_INBBEP16191, NRAM_INBHK
P03474, NRAM_INBLEP67923, NRAM_INBLNP16195, NRAM_INBMD
P67907, NRAM_INBMEP16199, NRAM_INBMFP16201, NRAM_INBOR
P16203, NRAM_INBSIP16205, NRAM_INBUSP16207, NRAM_INBVI
Q90021, NRAM_INBYBD4B4P1, SIA_ARTBCQ4WQS0, SIA_ASPFU
P23253, TCNA_TRYCR

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All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.2.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.2.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.-.-.-