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ENZYME entry: EC 3.2.1.180

Accepted Name
Unsaturated chondroitin disaccharide hydrolase.
Alternative Name(s)
Unsaturated glucuronyl hydrolase.
Reaction catalysed
Beta-D-4-deoxy-Delta(4)-GlcAp-(1->3)-beta-D-GalNAc6S + H(2)O <=> 5-dehydro-4-deoxy-D-glucuronate + N-acetyl-beta-D-galactosamine-6-O-sulfate
Comment(s)
  • The enzyme releases 4-deoxy-4,5-didehydro D-glucuronic acid or 4-deoxy-4,5-didehydro L-iduronic acid from chondroitin disaccharides, hyaluronan disaccharides and heparin disaccharides and cleaves both glycosidic (1->3) and (1->4) bonds.
  • It prefers the sulfated disaccharides to the unsulfated disaccharides.
Cross-references
BRENDA3.2.1.180
EC2PDB3.2.1.180
ExplorEnz3.2.1.180
PRIAM enzyme-specific profiles3.2.1.180
KEGG Ligand Database for Enzyme Nomenclature3.2.1.180
IUBMB Enzyme Nomenclature3.2.1.180
IntEnz3.2.1.180
MEDLINEFind literature relating to 3.2.1.180
MetaCyc3.2.1.180
Rhea expert-curated reactions3.2.1.180
UniProtKB/Swiss-Prot
Q8E372, UCDH_STRA3;  Q9A0T3, UCDH_STRP1;  Q8DR77, UCDH_STRR6;  

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