ENZYME entry: EC 3.2.1.180
| Accepted Name |
|---|
| Unsaturated chondroitin disaccharide hydrolase.
|
| Alternative Name(s) |
|---|
| Unsaturated glucuronyl hydrolase. |
| Reaction catalysed |
|---|
| Beta-D-4-deoxy-Delta(4)-GlcAp-(1->3)-beta-D-GalNAc6S + H(2)O <=> 5-dehydro-4-deoxy-D-glucuronate + N-acetyl-beta-D-galactosamine-6-O-sulfate |
| Comment(s) |
|---|
- The enzyme releases 4-deoxy-4,5-didehydro D-glucuronic acid or
4-deoxy-4,5-didehydro L-iduronic acid from chondroitin disaccharides,
hyaluronan disaccharides and heparin disaccharides and cleaves both
glycosidic (1->3) and (1->4) bonds.
- It prefers the sulfated disaccharides to the unsulfated
disaccharides.
|
| Cross-references |
|---|
| BRENDA | 3.2.1.180 |
| EC2PDB | 3.2.1.180 |
| ExplorEnz | 3.2.1.180 |
| PRIAM enzyme-specific profiles | 3.2.1.180 |
| KEGG Ligand Database for Enzyme Nomenclature | 3.2.1.180 |
| IUBMB Enzyme Nomenclature | 3.2.1.180 |
| IntEnz | 3.2.1.180 |
| MEDLINE | Find literature relating to 3.2.1.180 |
| MetaCyc | 3.2.1.180 |
| UniProtKB/Swiss-Prot |
|
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