A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.
ENZYME entry: EC 184.108.40.206
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|UDP-N-acetylglucosamine 2-epimerase (hydrolyzing).
|UDP-N-acetyl-alpha-D-glucosamine + H(2)O <=> N-acetyl-D-mannosamine + UDP|
- The enzyme is found in mammalian liver, as well as in some pathogenic
bacteria including Neisseria meningitidis and Staphylococcus aureus.
- It catalyzes the first step of sialic acid (N-acetylneuraminic acid)
- The initial product formed is the alpha anomer, which rapidly
mutarotates to a mixture of anomers.
- The mammalian enzyme is bifunctional and also catalyzes EC 220.127.116.11.
- Cf. EC 18.104.22.168.
|PRIAM enzyme-specific profiles||22.214.171.124|
|KEGG Ligand Database for Enzyme Nomenclature||126.96.36.199|
|IUBMB Enzyme Nomenclature||188.8.131.52|
|MEDLINE||Find literature relating to 184.108.40.206|
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