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ENZYME entry: EC 3.2.1.183

Accepted Name
UDP-N-acetylglucosamine 2-epimerase (hydrolyzing).
Alternative Name(s)
UDP-N-acetylglucosamine 2-epimerase.
Reaction catalysed
H2O + UDP-N-acetyl-alpha-D-glucosamine <=> H(+) + N-acetyl-D-mannosamine + UDP
Comment(s)
  • The enzyme is found in mammalian liver, as well as in some pathogenic bacteria including Neisseria meningitidis and Staphylococcus aureus.
  • It catalyzes the first step of sialic acid (N-acetylneuraminic acid) biosynthesis.
  • The initial product formed is the alpha anomer, which rapidly mutarotates to a mixture of anomers.
  • The mammalian enzyme is bifunctional and also catalyzes EC 2.7.1.60.
  • Cf. EC 5.1.3.14.
Cross-references
BRENDA3.2.1.183
EC2PDB3.2.1.183
ExplorEnz3.2.1.183
PRIAM enzyme-specific profiles3.2.1.183
KEGG Ligand Database for Enzyme Nomenclature3.2.1.183
IUBMB Enzyme Nomenclature3.2.1.183
IntEnz3.2.1.183
MEDLINEFind literature relating to 3.2.1.183
MetaCyc3.2.1.183
Rhea expert-curated reactions3.2.1.183
UniProtKB/Swiss-Prot
Q7TQ49, GLCNE_CRIGR;  Q9Y223, GLCNE_HUMAN;  Q91WG8, GLCNE_MOUSE;  
O35826, GLCNE_RAT;  H2VFI5, SIAA_NEIMB;  

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