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ENZYME

ENZYME entry: EC 3.2.1.183

PURL: https://purl.expasy.org/enzyme/EC/3.2.1.183
Accepted Name
UDP-N-acetylglucosamine 2-epimerase (hydrolyzing)
Alternative Name(s)
UDP-N-acetylglucosamine 2-epimerase
Reaction catalysed
UDP-N-acetyl-alpha-D-glucosamine + H2O = aldehydo-N-acetyl-D-mannosamine + UDP + H(+)
Comment(s)
  • The enzyme is found in mammalian liver, as well as in some pathogenic bacteria including Neisseria meningitidis and Staphylococcus aureus.
  • It catalyzes the first step of sialic acid (N-acetylneuraminic acid) biosynthesis.
  • The initial product formed is the alpha anomer, which rapidly mutarotates to a mixture of anomers.
  • The mammalian enzyme is bifunctional and also catalyzes EC 2.7.1.60. cf. EC 5.1.3.14.
Cross-references
BRENDA3.2.1.183
EC2PDB3.2.1.183
ExplorEnz3.2.1.183
KEGG Ligand Database for Enzyme Nomenclature3.2.1.183
IUBMB Enzyme Nomenclature3.2.1.183
MEDLINEFind literature relating to 3.2.1.183
MetaCyc3.2.1.183
Rhea expert-curated reactions3.2.1.183
UniProtKB/Swiss-Prot
Q7TQ49, GLCNE_CRIGRQ9Y223, GLCNE_HUMANQ91WG8, GLCNE_MOUSE
O35826, GLCNE_RATH2VFI5, SIAA_NEIMBP0DY05, UAEPH_CAMJ8

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.2.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.2.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.-.-.-