A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.
ENZYME entry: EC 3.2.1.183
Accepted Name |
UDP-N-acetylglucosamine 2-epimerase (hydrolyzing).
|
Alternative Name(s) |
UDP-N-acetylglucosamine 2-epimerase. |
Reaction catalysed |
UDP-N-acetyl-alpha-D-glucosamine + H(2)O <=> N-acetyl-D-mannosamine + UDP |
Comment(s) |
- The enzyme is found in mammalian liver, as well as in some pathogenic
bacteria including Neisseria meningitidis and Staphylococcus aureus.
- It catalyzes the first step of sialic acid (N-acetylneuraminic acid)
biosynthesis.
- The initial product formed is the alpha anomer, which rapidly
mutarotates to a mixture of anomers.
- The mammalian enzyme is bifunctional and also catalyzes EC 2.7.1.60.
- Cf. EC 5.1.3.14.
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Cross-references |
BRENDA | 3.2.1.183 |
EC2PDB | 3.2.1.183 |
ExplorEnz | 3.2.1.183 |
PRIAM enzyme-specific profiles | 3.2.1.183 |
KEGG Ligand Database for Enzyme Nomenclature | 3.2.1.183 |
IUBMB Enzyme Nomenclature | 3.2.1.183 |
IntEnz | 3.2.1.183 |
MEDLINE | Find literature relating to 3.2.1.183 |
MetaCyc | 3.2.1.183 |
UniProtKB/Swiss-Prot |
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ENZYME /
UniProtKB/Swiss-Prot entries corresponding to 3.2.1.-
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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.-.-.-