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ENZYME

ENZYME entry: EC 3.2.1.184

PURL: https://purl.expasy.org/enzyme/EC/3.2.1.184
Accepted Name
UDP-N,N'-diacetylbacillosamine 2-epimerase (hydrolyzing)
Alternative Name(s)
UDP-Bac2Ac4Ac 2-epimerase
Reaction catalysed
UDP-N,N'-diacetylbacillosamine + H2O = 2,4-diacetamido-2,4,6-trideoxy-alpha-D-mannopyranose + UDP + H(+)
Comment(s)
  • Involved in biosynthesis of legionaminic acid, a nonulosonate derivative that is incorporated by some bacteria into assorted virulence-associated cell surface glycoconjugates.
  • The initial product formed by the enzyme from Legionella pneumophila, which incorporates legionaminic acid into the O-antigen moiety of its lipopolysaccharide, is 2,4-diacetamido-2,4,6-trideoxy-alpha-D- mannopyranose, which rapidly mutarotates to a mixture of anomers.
  • The enzyme from Campylobacter jejuni, which incorporates legionaminic acid into flagellin, prefers GDP-N,N'-diacetylbacillosamine.
Cross-references
BRENDA3.2.1.184
EC2PDB3.2.1.184
ExplorEnz3.2.1.184
KEGG Ligand Database for Enzyme Nomenclature3.2.1.184
IUBMB Enzyme Nomenclature3.2.1.184
MEDLINEFind literature relating to 3.2.1.184
MetaCyc3.2.1.184
Rhea expert-curated reactions3.2.1.184
UniProtKB/Swiss-Prot
Q0P8T0, NEUCH_CAMJEQ5ZXH8, NEUCH_LEGPH

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.2.1.-
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