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ENZYME entry: EC 3.2.1.207

Accepted Name
Mannosyl-oligosaccharide alpha-1,3-glucosidase.
Alternative Name(s)
Alpha-glucosidase II.
ER glucosidase II.
Trimming glucosidase II.
Reaction catalysed
  • Glc(2)Man(9)GlcNAc(2)-[protein] + H(2)O <=> GlcMan(9)GlcNAc(2)-[protein] + beta-D-glucopyranose
  • GlcMan(9)GlcNAc(2)-[protein] + H(2)O <=> Man(9)GlcNAc(2)-[protein] + beta-D-glucopyranose
Comment(s)
This eukaryotic enzyme cleaves off sequentially the two alpha-1,3- linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature N-glycosylated proteins.
Cross-references
BRENDA3.2.1.207
EC2PDB3.2.1.207
ExplorEnz3.2.1.207
PRIAM enzyme-specific profiles3.2.1.207
KEGG Ligand Database for Enzyme Nomenclature3.2.1.207
IUBMB Enzyme Nomenclature3.2.1.207
IntEnz3.2.1.207
MEDLINEFind literature relating to 3.2.1.207
MetaCyc3.2.1.207
UniProtKB/Swiss-Prot
Q94502, GANAB_DICDI;  Q14697, GANAB_HUMAN;  Q4R4N7, GANAB_MACFA;  
Q8BHN3, GANAB_MOUSE;  P79403, GANAB_PIG;  B9F676, GLU2A_ORYSJ;  
Q9US55, GLU2A_SCHPO;  P38138, GLU2A_YEAST;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.2.1.-
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