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ENZYME entry: EC 3.2.1.207

Accepted Name
mannosyl-oligosaccharide alpha-1,3-glucosidase.
Alternative Name(s)
alpha-glucosidase II.
ER glucosidase II.
trimming glucosidase II.
Reaction catalysed
  • H2O + N(4)-(alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] <=> beta-D-glucose + N(4)-(alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein]
  • H2O + N(4)-(alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] <=> beta-D-glucose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3)
Comment(s)
This eukaryotic enzyme cleaves off sequentially the two alpha-1,3- linked glucose residues from the Glc2Man9GlcNAc2 oligosaccharide precursor of immature N-glycosylated proteins.
Cross-references
BRENDA3.2.1.207
EC2PDB3.2.1.207
ExplorEnz3.2.1.207
PRIAM enzyme-specific profiles3.2.1.207
KEGG Ligand Database for Enzyme Nomenclature3.2.1.207
IUBMB Enzyme Nomenclature3.2.1.207
IntEnz3.2.1.207
MEDLINEFind literature relating to 3.2.1.207
MetaCyc3.2.1.207
Rhea expert-curated reactions3.2.1.207
UniProtKB/Swiss-Prot
Q94502, GANAB_DICDI;  Q14697, GANAB_HUMAN;  Q4R4N7, GANAB_MACFA;  
Q8BHN3, GANAB_MOUSE;  P79403, GANAB_PIG;  B9F676, GLU2A_ORYSJ;  
Q9US55, GLU2A_SCHPO;  P38138, GLU2A_YEAST;  

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