ENZYME entry: EC 188.8.131.52
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|Endoplasmic reticulum Man(9)GlcNAc(2) 1,2-alpha-mannosidase.
|Man(9)GlcNAc(2)-[protein] + H(2)O <=> Man(8)GlcNAc(2)-[protein] (isomer 8A(1,2,3)B(1,3)) + D-mannopyranose|
- The enzyme, located in the endoplasmic reticulum, primarily trims a
single alpha-1,2-linked mannose residue from Man(9)GlcNAc(2) to
produce Man(8)GlcNAc(2) isomer 8A(1,2,3)B(1,3) (the names of the
isomers listed here are based on a nomenclature system proposed by
Prien et al (pmid:19181540)).
- The removal of the single mannosyl residue occurs in all eukaryotes
as part of the processing of N-glycosylated proteins, and is
absolutely essential for further elongation of the outer chain of
properly-folded N-glycosylated proteins in yeast.
- In addition, the enzyme is involved in glycoprotein quality control
at the ER quality control compartment (ERQC), helping to target
misfolded glycoproteins for degradation.
- When present at very high concentrations in the ERQC, the enzyme can
trim the carbohydrate chain further to Man(5-6)GlcNAc(2).
|PRIAM enzyme-specific profiles||184.108.40.206|
|KEGG Ligand Database for Enzyme Nomenclature||220.127.116.11|
|IUBMB Enzyme Nomenclature||18.104.22.168|
|MEDLINE||Find literature relating to 22.214.171.124|
|Rhea expert-curated reactions||126.96.36.199|
entries corresponding to 3.2.1.-
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