ENZYME entry: EC 3.2.1.209
| Accepted Name |
|---|
| Endoplasmic reticulum Man(9)GlcNAc(2) 1,2-alpha-mannosidase.
|
| Reaction catalysed |
|---|
| Man(9)GlcNAc(2)-[protein] + H(2)O <=> Man(8)GlcNAc(2)-[protein] (isomer 8A(1,2,3)B(1,3)) + D-mannopyranose |
| Comment(s) |
|---|
- The enzyme, located in the endoplasmic reticulum, primarily trims a
single alpha-1,2-linked mannose residue from Man(9)GlcNAc(2) to
produce Man(8)GlcNAc(2) isomer 8A(1,2,3)B(1,3) (the names of the
isomers listed here are based on a nomenclature system proposed by
Prien et al (pmid:19181540)).
- The removal of the single mannosyl residue occurs in all eukaryotes
as part of the processing of N-glycosylated proteins, and is
absolutely essential for further elongation of the outer chain of
properly-folded N-glycosylated proteins in yeast.
- In addition, the enzyme is involved in glycoprotein quality control
at the ER quality control compartment (ERQC), helping to target
misfolded glycoproteins for degradation.
- When present at very high concentrations in the ERQC, the enzyme can
trim the carbohydrate chain further to Man(5-6)GlcNAc(2).
|
| Cross-references |
|---|
| BRENDA | 3.2.1.209 |
| EC2PDB | 3.2.1.209 |
| ExplorEnz | 3.2.1.209 |
| PRIAM enzyme-specific profiles | 3.2.1.209 |
| KEGG Ligand Database for Enzyme Nomenclature | 3.2.1.209 |
| IUBMB Enzyme Nomenclature | 3.2.1.209 |
| IntEnz | 3.2.1.209 |
| MEDLINE | Find literature relating to 3.2.1.209 |
| MetaCyc | 3.2.1.209 |
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ENZYME /
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