ID   3.2.1.210
DE   endoplasmic reticulum Man8GlcNAc2 1,2-alpha-mannosidase.
CA   H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-
CA   [alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-
CA   (1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-
CA   asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3) = beta-D-
CA   mannose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-
CA   [alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-
CA   (1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein]
CA   (N-glucan mannose isomer 7A1,2,3B3).
CC   -!- In yeast this activity is catalyzed by a dedicated enzyme that
CC       processes unfolded protein-bound Man8GlcNAc2 N-glycans within the
CC       endoplasmic reticulum to Man7GlcNAc2.
CC   -!- The exposed alpha-1,6-linked mannose residue in the product enables
CC       the recognition by the YOS9 lectin, targeting the proteins for
CC       degradation.
CC   -!- In mammalian cells this activity is part of the regular processing of
CC       N-glycosylated proteins, and is not associated with protein
CC       degradation.
CC   -!- It is carried out by EC 3.2.1.113.
CC   -!- The names of the isomers listed here are based on a nomenclature
CC       system proposed by Prien et al.
//