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ENZYME entry: EC 3.2.1.62
Accepted Name |
glycosylceramidase.
|
Alternative Name(s) |
cerebrosidase. |
glycosyl ceramide glycosylhydrolase. |
glycosyl-N-acylsphingosine glycohydrolase. |
lactase-phlorizin hydrolase. |
phloretin-glucosidase. |
phloridzin beta-glucosidase. |
phloridzin glucosidase. |
phlorizin hydrolase. |
Reaction catalysed |
- glycosyl-N-acylsphingosine + H2O <=> N-acylsphingosine + a sugar
- a beta-D-galactosyl-N-acylsphingosine + H2O <=> a ceramide + beta-D-galactose
- a flavonoid-O-beta-D-glucoside + H2O <=> a flavonoid + beta-D-glucose
|
Comment(s) |
- The enzyme, found in the intestinal mucosa, hydrolyzes beta-D-
glucosyl and beta-D-galactosyl residues from a very broad range of
substrates using a retaining mechanism.
- Characterized substrates include glucosyl- and galactosyl-ceramides,
O(3)-, O(4') and O(7)-glucosylated flavonoids, and the 2'-O-
glucosylated dihydrochalcone phlorizin.
- The enzyme includes two glycosyl hydrolase domains, both belonging to
the GH1 family.
- While one domain is responsible for the activity described here,
the other catalyzes the reaction of EC 3.2.1.108. cf. EC 3.2.1.45 and
EC 3.2.1.46.
|
Cross-references |
BRENDA | 3.2.1.62 |
EC2PDB | 3.2.1.62 |
ExplorEnz | 3.2.1.62 |
PRIAM enzyme-specific profiles | 3.2.1.62 |
KEGG Ligand Database for Enzyme Nomenclature | 3.2.1.62 |
IUBMB Enzyme Nomenclature | 3.2.1.62 |
IntEnz | 3.2.1.62 |
MEDLINE | Find literature relating to 3.2.1.62 |
MetaCyc | 3.2.1.62 |
Rhea expert-curated reactions | 3.2.1.62 |
UniProtKB/Swiss-Prot |
|
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ENZYME /
UniProtKB/Swiss-Prot entries corresponding to 3.2.1.-
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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.-.-.-