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ENZYME entry: EC 3.2.1.62
| Accepted Name |
|---|
| glycosylceramidase.
|
| Alternative Name(s) |
|---|
| cerebrosidase. |
| glycosyl ceramide glycosylhydrolase. |
| glycosyl-N-acylsphingosine glycohydrolase. |
| lactase-phlorizin hydrolase. |
| phloretin-glucosidase. |
| phloridzin beta-glucosidase. |
| phloridzin glucosidase. |
| phlorizin hydrolase. |
| Reaction catalysed |
|---|
- glycosyl-N-acylsphingosine + H2O <=> N-acylsphingosine + a sugar
- a beta-D-galactosyl-N-acylsphingosine + H2O <=> a ceramide + beta-D-galactose
- a flavonoid-O-beta-D-glucoside + H2O <=> a flavonoid + beta-D-glucose
|
| Comment(s) |
|---|
- The enzyme, found in the intestinal mucosa, hydrolyzes beta-D-
glucosyl and beta-D-galactosyl residues from a very broad range of
substrates using a retaining mechanism.
- Characterized substrates include glucosyl- and galactosyl-ceramides,
O(3)-, O(4') and O(7)-glucosylated flavonoids, and the 2'-O-
glucosylated dihydrochalcone phlorizin.
- The enzyme includes two glycosyl hydrolase domains, both belonging to
the GH1 family.
- While one domain is responsible for the activity described here,
the other catalyzes the reaction of EC 3.2.1.108. cf. EC 3.2.1.45 and
EC 3.2.1.46.
|
| Cross-references |
|---|
| BRENDA | 3.2.1.62 |
| EC2PDB | 3.2.1.62 |
| ExplorEnz | 3.2.1.62 |
| PRIAM enzyme-specific profiles | 3.2.1.62 |
| KEGG Ligand Database for Enzyme Nomenclature | 3.2.1.62 |
| IUBMB Enzyme Nomenclature | 3.2.1.62 |
| IntEnz | 3.2.1.62 |
| MEDLINE | Find literature relating to 3.2.1.62 |
| MetaCyc | 3.2.1.62 |
| Rhea expert-curated reactions | 3.2.1.62 |
| UniProtKB/Swiss-Prot |
|
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ENZYME /
UniProtKB/Swiss-Prot entries corresponding to 3.2.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.2.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.-.-.-