A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.
ENZYME entry: EC 3.2.1.97
| Accepted Name |
|---|
| Endo-alpha-N-acetylgalactosaminidase.
|
| Alternative Name(s) |
|---|
| D-galactosyl-3-(N-acetyl-alpha-D-galactosaminyl)-L-serine
mucinaminohydrolase. |
| D-galactosyl-N-acetyl-alpha-D-galactosamine D-galactosyl-N-acetyl-
galactosaminohydrolase. |
| Endo-alpha-acetylgalactosaminidase. |
| Endo-alpha-GalNAc-ase. |
| Endo-alpha-N-acetyl-D-galactosaminidase. |
| Glycopeptide alpha-N-acetylgalactosaminidase. |
| Mucinaminylserine mucinaminidase. |
| Reaction catalysed |
|---|
| Beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-L-serine/L-threonine-[protein] + H(2)O <=> beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosamine + L-serine/L-threonine-[protein] |
| Comment(s) |
|---|
- The enzyme catalyzes the liberation of Gal-(1->3)-beta-GalNAc alpha-
linked to serine or threonine residues of mucin-type glycoproteins.
- EngBF from Bifidobacterium longum specifically acts on core 1-type
O-glycan to release the disaccharide Gal-(1->3)-beta-GalNAc.
- The enzymes from Clostridium perfringens, Enterococcus faecalis,
Propionibacterium acnes and Alcaligenes faecalis show broader
specificity (e.g. release of the core 2 trisaccharide Gal-(1->3)-
beta-(GlcNAc-(1->6)-beta)-GalNAc or the core 3 disaccharide GlcNAc-
(1->3)-beta-GalNAc).
- The enzyme may play an important role in the degradation and
utilization of mucins having core 1 O-glycan.
- Formerly EC 3.2.1.110.
|
| Cross-references |
|---|
| BRENDA | 3.2.1.97 |
| EC2PDB | 3.2.1.97 |
| ExplorEnz | 3.2.1.97 |
| PRIAM enzyme-specific profiles | 3.2.1.97 |
| KEGG Ligand Database for Enzyme Nomenclature | 3.2.1.97 |
| IUBMB Enzyme Nomenclature | 3.2.1.97 |
| IntEnz | 3.2.1.97 |
| MEDLINE | Find literature relating to 3.2.1.97 |
| MetaCyc | 3.2.1.97 |
| UniProtKB/Swiss-Prot |
|
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ENZYME /
UniProtKB/Swiss-Prot entries corresponding to 3.2.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.2.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.-.-.-