ENZYME entry: EC 3.2.1.97
Accepted Name |
Endo-alpha-N-acetylgalactosaminidase.
|
Alternative Name(s) |
D-galactosyl-3-(N-acetyl-alpha-D-galactosaminyl)-L-serine
mucinaminohydrolase. |
D-galactosyl-N-acetyl-alpha-D-galactosamine D-galactosyl-N-acetyl-
galactosaminohydrolase. |
Endo-alpha-acetylgalactosaminidase. |
Endo-alpha-GalNAc-ase. |
Endo-alpha-N-acetyl-D-galactosaminidase. |
Glycopeptide alpha-N-acetylgalactosaminidase. |
Mucinaminylserine mucinaminidase. |
Reaction catalysed |
Beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-L-serine/L-threonine-[protein] + H(2)O <=> beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosamine + L-serine/L-threonine-[protein] |
Comment(s) |
- The enzyme catalyzes the liberation of Gal-(1->3)-beta-GalNAc alpha-
linked to serine or threonine residues of mucin-type glycoproteins.
- EngBF from Bifidobacterium longum specifically acts on core 1-type
O-glycan to release the disaccharide Gal-(1->3)-beta-GalNAc.
- The enzymes from Clostridium perfringens, Enterococcus faecalis,
Propionibacterium acnes and Alcaligenes faecalis show broader
specificity (e.g. release of the core 2 trisaccharide Gal-(1->3)-
beta-(GlcNAc-(1->6)-beta)-GalNAc or the core 3 disaccharide GlcNAc-
(1->3)-beta-GalNAc).
- The enzyme may play an important role in the degradation and
utilization of mucins having core 1 O-glycan.
- Formerly EC 3.2.1.110.
|
Cross-references |
BRENDA | 3.2.1.97 |
EC2PDB | 3.2.1.97 |
ExplorEnz | 3.2.1.97 |
PRIAM enzyme-specific profiles | 3.2.1.97 |
KEGG Ligand Database for Enzyme Nomenclature | 3.2.1.97 |
IUBMB Enzyme Nomenclature | 3.2.1.97 |
IntEnz | 3.2.1.97 |
MEDLINE | Find literature relating to 3.2.1.97 |
MetaCyc | 3.2.1.97 |
Rhea expert-curated reactions | 3.2.1.97 |
UniProtKB/Swiss-Prot |
|
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