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ENZYME

ENZYME entry: EC 3.2.2.29

PURL: https://purl.expasy.org/enzyme/EC/3.2.2.29
Accepted Name
thymine-DNA glycosylase
Alternative Name(s)
mismatch-specific thymine-DNA glycosylase
mismatch-specific thymine-DNA N-glycosylase
TDG
thymine DNA glycosylase
uracil/thymine DNA glycosylase
Reaction catalysed
Hydrolyzes mismatched double-stranded DNA and polynucleotides, releasing free thymine
Comment(s)
  • Thymine-DNA glycosylase is part of the DNA-repair machinery.
  • Thymine removal is fastest when it is from a G/T mismatch with a 5'-flanking C/G pair.
  • The glycosylase removes uracil from G/U, C/U, and T/U base pairs faster than it removes thymine from G/T.
Cross-references
BRENDA3.2.2.29
EC2PDB3.2.2.29
ExplorEnz3.2.2.29
KEGG Ligand Database for Enzyme Nomenclature3.2.2.29
IUBMB Enzyme Nomenclature3.2.2.29
MEDLINEFind literature relating to 3.2.2.29
MetaCyc3.2.2.29
Rhea expert-curated reactions3.2.2.29
UniProtKB/Swiss-Prot
Q9YDP0, MIG_AERPEP29588, MIG_METTFQ7LX22, MIG_PYRAE
Q13569, TDG_HUMANP56581, TDG_MOUSE

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.2.2.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.2.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.-.-.-