ENZYME entry: EC 3.2.2.29
Accepted Name |
Thymine-DNA glycosylase.
|
Alternative Name(s) |
Mismatch-specific thymine-DNA glycosylase. |
Mismatch-specific thymine-DNA N-glycosylase. |
TDG. |
Thymine DNA glycosylase. |
Uracil/thymine DNA glycosylase. |
Reaction catalysed |
Hydrolyzes mismatched double-stranded DNA and polynucleotides, releasing free thymine |
Comment(s) |
- Thymine-DNA glycosylase is part of the DNA-repair machinery.
- Thymine removal is fastest when it is from a G/T mismatch with a
5'-flanking C/G pair.
- The glycosylase removes uracil from G/U, C/U, and T/U base pairs
faster than it removes thymine from G/T.
|
Cross-references |
BRENDA | 3.2.2.29 |
EC2PDB | 3.2.2.29 |
ExplorEnz | 3.2.2.29 |
PRIAM enzyme-specific profiles | 3.2.2.29 |
KEGG Ligand Database for Enzyme Nomenclature | 3.2.2.29 |
IUBMB Enzyme Nomenclature | 3.2.2.29 |
IntEnz | 3.2.2.29 |
MEDLINE | Find literature relating to 3.2.2.29 |
MetaCyc | 3.2.2.29 |
Rhea expert-curated reactions | 3.2.2.29 |
UniProtKB/Swiss-Prot |
|
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