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ENZYME entry: EC 3.2.2.29

Accepted Name
Thymine-DNA glycosylase.
Alternative Name(s)
Mismatch-specific thymine-DNA glycosylase.
Mismatch-specific thymine-DNA N-glycosylase.
TDG.
Thymine DNA glycosylase.
Uracil/thymine DNA glycosylase.
Reaction catalysed
Hydrolyzes mismatched double-stranded DNA and polynucleotides, releasing free thymine
Comment(s)
  • Thymine-DNA glycosylase is part of the DNA-repair machinery.
  • Thymine removal is fastest when it is from a G/T mismatch with a 5'-flanking C/G pair.
  • The glycosylase removes uracil from G/U, C/U, and T/U base pairs faster than it removes thymine from G/T.
Cross-references
BRENDA3.2.2.29
EC2PDB3.2.2.29
ExplorEnz3.2.2.29
PRIAM enzyme-specific profiles3.2.2.29
KEGG Ligand Database for Enzyme Nomenclature3.2.2.29
IUBMB Enzyme Nomenclature3.2.2.29
IntEnz3.2.2.29
MEDLINEFind literature relating to 3.2.2.29
MetaCyc3.2.2.29
UniProtKB/Swiss-Prot
Q13569, TDG_HUMAN;  P56581, TDG_MOUSE;  

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