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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC

Accepted Name
Thymine-DNA glycosylase.
Alternative Name(s)
Mismatch-specific thymine-DNA glycosylase.
Mismatch-specific thymine-DNA N-glycosylase.
Thymine DNA glycosylase.
Uracil/thymine DNA glycosylase.
Reaction catalysed
Hydrolyzes mismatched double-stranded DNA and polynucleotides, releasing free thymine
  • Thymine-DNA glycosylase is part of the DNA-repair machinery.
  • Thymine removal is fastest when it is from a G/T mismatch with a 5'-flanking C/G pair.
  • The glycosylase removes uracil from G/U, C/U, and T/U base pairs faster than it removes thymine from G/T.
PRIAM enzyme-specific profiles3.2.2.29
KEGG Ligand Database for Enzyme Nomenclature3.2.2.29
IUBMB Enzyme Nomenclature3.2.2.29
MEDLINEFind literature relating to
Q13569, TDG_HUMAN;  P56581, TDG_MOUSE;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.2.2.-
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