ID   3.2.2.31
DE   adenine glycosylase.
AN   A/G-specific adenine glycosylase.
CA   Hydrolyzes free adenine bases from 7,8-dihydro-8-oxoguanine:adenine
CA   mismatched double-stranded DNA, leaving an apurinic site.
CC   -!- The enzyme serves as a mismatch repair enzyme that works to correct
CC       7,8-dihydro-8-oxoguanine:adenine mispairs that arise in DNA when
CC       error-prone synthesis occurs past 7,8-dihydro-8-oxoguanine (GO)
CC       lesions in DNA.
CC   -!- The enzyme excises the adenine of the mispair, producing an apurinic
CC       site sensitive to AP endonuclease activity.
CC   -!- After removing the undamaged adenine the enzyme remains bound to the
CC       site to prevent EC 3.2.2.23 (MutM) from removing the GO lesion, which
CC       could lead to a double strand break.
CC   -!- In vitro the enzyme is also active with adenine:guanine,
CC       adenine:cytosine, and adenine:7,8-dihydro-8-oxoadenine (AO) mispairs,
CC       removing the adenine in all cases.
DR   F4JRF4, MUTYH_ARATH;  Q9UIF7, MUTYH_HUMAN;  Q99P21, MUTYH_MOUSE;
DR   Q8R5G2, MUTYH_RAT  ;  P46230, MUTY_AERHY ;  O31584, MUTY_BACSU ;
DR   P57617, MUTY_BUCAI ;  Q8K926, MUTY_BUCAP ;  Q89A45, MUTY_BUCBP ;
DR   P17802, MUTY_ECOLI ;  P83847, MUTY_GEOSE ;  P44320, MUTY_HAEIN ;
DR   A0R567, MUTY_MYCS2 ;  P9WQ08, MUTY_MYCTO ;  P9WQ09, MUTY_MYCTU ;
DR   Q05869, MUTY_SALTY ;  Q10159, MYH1_SCHPO ;
//