ID   3.2.2.5
DE   NAD(+) glycohydrolase.
AN   ADP-ribosyl cyclase.
AN   beta-NAD(+) glycohydrolase.
AN   diphosphopyridine nucleosidase.
AN   DPNase.
AN   DPN hydrolase.
AN   NAD(+) nucleosidase.
AN   NADase.
AN   NAD glycohydrolase.
AN   NAD nucleosidase.
AN   nicotinamide adenine dinucleotide glycohydrolase.
AN   nicotinamide adenine dinucleotide nucleosidase.
CA   H2O + NAD(+) = ADP-D-ribose + H(+) + nicotinamide.
CC   -!- This enzyme catalyzes the hydrolysis of NAD(+), without associated
CC       ADP-ribosyl cyclase activity (unlike the metazoan enzyme EC 3.2.2.6,
CC       bifunctional ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase).
CC   -!- The enzyme from Group A streptococci has been implicated in the
CC       pathogenesis of diseases such as streptococcal toxic shock-like
CC       syndrome (STSS) and necrotizing fasciitis.
CC   -!- The enzyme from the venom of the snake Agkistrodon acutus also
CC       catalyzes EC 3.6.1.5.
DR   A0A5D0EMF2, CAP12_AGGAC;  A0A381HAP5, CAP12_CAPGB;  P0DUD9, CAP12_FLADA;
DR   P0DUE0, CAP12_LACSX;  A0A1G6LGU2, CAP12_NIADE;  A0A2T5Y4G4, CAP12_SPHFK;
DR   A0A0H3MAA9, CPNT_MYCBP ;  O05442, CPNT_MYCTU ;  Q4WL81, NADA_ASPFU ;
DR   Q7S936, NADA_NEUCR ;  P17981, NAR2A_MOUSE;  P17982, NAR2A_RAT  ;
DR   O35975, NAR2B_MOUSE;  P20974, NAR2B_RAT  ;  A0A0J5WTU0, PCTIR_BURCE;
DR   P0DV41, PCTIR_PSEAI;  A0A1V0HUU2, PCTIR_RHOS2;  P0DV29, PCTIR_XANPE;
DR   P0DW59, THSA_ACIB7 ;  J8G6Z1, THSA_BACCS ;  A0A5B8Z1N3, THSA_BACDA ;
DR   P0DW60, THSA_ENTFC ;  C0MAL8, THSA_STRE4 ;  Q9I739, TSE6_PSEAE ;
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