ID   3.3.2.10
DE   soluble epoxide hydrolase.
AN   arene-oxide hydratase.
AN   aryl epoxide hydrase.
AN   cytosolic epoxide hydrolase.
AN   epoxide hydrase.
AN   epoxide hydratase.
AN   trans-stilbene oxide hydrolase.
CA   an epoxide + H2O = an ethanediol.
CC   -!- Catalyzes the hydrolysis of trans-substituted epoxides, such as
CC       trans-stilbene oxide, as well as various aliphatic epoxides derived
CC       from fatty-acid metabolism.
CC   -!- It is involved in the metabolism of arachidonic epoxides
CC       (epoxyeicosatrienoic acids; EETs) and linoleic acid epoxides.
CC   -!- The enzyme from mammals is a bifunctional enzyme: the C-terminal
CC       domain exhibits epoxide-hydrolase activity and the N-terminal domain
CC       has the activity of EC 3.1.3.76.
CC   -!- Like EC 3.3.2.9, it is probable that the reaction involves the
CC       formation of an hydroxyalkyl-enzyme intermediate.
CC   -!- The enzyme can also use leukotriene A4, the substrate of EC 3.3.2.6,
CC       but it forms 5,6-dihydroxy-7,9,11,14-eicosatetraenoic acid rather
CC       than leukotriene B4 as the product.
CC   -!- Formerly EC 3.3.2.3, EC 4.2.1.63 and EC 4.2.1.64.
DR   G5EBI4, CEEH1_CAEEL;  G5EDL5, CEEH2_CAEEL;  P0DO68, EPH1_SIRGR ;
DR   P0DO69, EPH2_SIRGR ;  P0DO70, EPH3_SIRGR ;  I6YGS0, EPHA_MYCTU ;
DR   P95276, EPHB_MYCTO ;  I6YC03, EPHB_MYCTU ;  O33283, EPHG_MYCTU ;
DR   O53388, EPHH_MYCTU ;  Q9H6B9, EPHX3_HUMAN;  Q3V1F8, EPHX3_MOUSE;
DR   Q0IIS3, EPHX3_XENTR;  A0A126P745, EPOXH_BOSS2;  A0A242M8J4, EPOXH_CABSO;
DR   P80048, HYEP_PSEU1 ;  Q06816, HYEP_STIAD ;  O52866, HYES_CORS2 ;
DR   P34913, HYES_HUMAN ;  P34914, HYES_MOUSE ;  Q6Q2C2, HYES_PIG   ;
DR   P80299, HYES_RAT   ;  A5DME6, LKA41_PICGU;  A3LRX6, LKA41_PICST;
DR   A5DGF3, LKA42_PICGU;  A3LQI7, LKA42_PICST;  A6RCT2, LKHA4_AJECN;
DR   Q9FY49, LKHA4_ARATH;  A1CSI2, LKHA4_ASPCL;  Q4X265, LKHA4_ASPFU;
DR   A2QKF8, LKHA4_ASPNC;  Q2TZ99, LKHA4_ASPOR;  Q0CFY9, LKHA4_ASPTN;
DR   Q59NB8, LKHA4_CANAL;  Q6FTM0, LKHA4_CANGA;  Q2GY21, LKHA4_CHAGB;
DR   Q1DVD1, LKHA4_COCIM;  Q6BW21, LKHA4_DEBHA;  P52922, LKHA4_DICDI;
DR   Q5B0W8, LKHA4_EMENI;  Q75B10, LKHA4_EREGS;  Q6CLD3, LKHA4_KLULA;
DR   A5DSS4, LKHA4_LODEL;  A1DG68, LKHA4_NEOFI;  Q7S785, LKHA4_NEUCR;
DR   Q84TA3, LKHA4_ORYSJ;  Q0U653, LKHA4_PHANO;  A4QUC1, LKHA4_PYRO7;
DR   O94544, LKHA4_SCHPO;  A7EJL9, LKHA4_SCLS1;  A7THG7, LKHA4_VANPO;
DR   Q6C3E5, LKHA4_YARLI;  A6ZS33, LKHA4_YEAS7;  Q10740, LKHA4_YEAST;
//