ID   3.3.2.11
DE   cholesterol-5,6-oxide hydrolase.
AN   ChEH.
AN   cholesterol-epoxide hydrolase.
CA   (1) 5,6alpha-epoxy-5alpha-cholestan-3beta-ol + H2O = 5alpha-cholestane-
CA   3beta,5,6beta-triol.
CA   (2) 5,6beta-epoxy-5beta-cholestan-3beta-ol + H2O = 5alpha-cholestane-
CA   3beta,5,6beta-triol.
CC   -!- The activity has been attributed to the microsomal antiestrogen
CC       binding site, a complex formed by EC 5.3.3.5 and EC 1.3.1.21.
CC   -!- Both 5,6alpha-epoxy-5alpha-cholestan-3beta-ol and 5,6beta-epoxy-
CC       5beta-cholestan-3beta-ol are substrates.
CC   -!- The product is a competitive inhibitor of the reaction.
CC   -!- In vertebrates, five epoxide-hydrolase enzymes have been identified
CC       to date: EC 3.3.2.6, EC 3.3.2.7, EC 3.3.2.9, EC 3.3.2.10,
CC       and EC 3.3.2.11.
DR   Q5E9J5, DHCR7_BOVIN;  Q9UBM7, DHCR7_HUMAN;  O88455, DHCR7_MOUSE;
DR   Q9Z2Z8, DHCR7_RAT  ;  Q60490, EBP_CAVPO  ;  Q15125, EBP_HUMAN  ;
DR   P70245, EBP_MOUSE  ;  Q9JJ46, EBP_RAT    ;  O33283, EPHG_MYCTU ;
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